1k2o

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[[Image:1k2o.gif|left|200px]]
[[Image:1k2o.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1k2o |SIZE=350|CAPTION= <scene name='initialview01'>1k2o</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_1k2o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RFA:DELTA-BIS(2,2&#39;-BIPYRIDINE)-(5-METHYL-2-2&#39;-BIPYRIDINE)-C2-ADAMANTANE+RUTHENIUM+(II)'>RFA</scene>, <scene name='pdbligand=RFB:LAMBDA-BIS(2,2&#39;-BIPYRIDINE)-(5-METHYL-2-2&#39;-BIPYRIDINE)-C2-ADAMANTANE+RUTHENIUM+(II)'>RFB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Camphor_5-monooxygenase Camphor 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.15.1 1.14.15.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1k2o| PDB=1k2o | SCENE= }}
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|RELATEDENTRY=[[2cpp|2CPP]], [[1qmq|1QMQ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2o OCA], [http://www.ebi.ac.uk/pdbsum/1k2o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k2o RCSB]</span>
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}}
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'''Cytochrome P450Cam with Bound BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II)'''
'''Cytochrome P450Cam with Bound BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II)'''
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[[Category: Dunn, A R.]]
[[Category: Dunn, A R.]]
[[Category: Gray, H B.]]
[[Category: Gray, H B.]]
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[[Category: adamantane]]
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[[Category: Adamantane]]
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[[Category: biphenyl]]
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[[Category: Biphenyl]]
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[[Category: electron transfer]]
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[[Category: Electron transfer]]
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[[Category: energy transfer]]
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[[Category: Energy transfer]]
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[[Category: fluorinated aromatic]]
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[[Category: Fluorinated aromatic]]
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[[Category: monooxygenase]]
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[[Category: Monooxygenase]]
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[[Category: p450]]
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[[Category: P450]]
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[[Category: ruthenium channel]]
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[[Category: Ruthenium channel]]
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[[Category: substrate-binding]]
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[[Category: Substrate-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:13:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:42:32 2008''
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Revision as of 19:13, 2 May 2008

Image:1k2o.gif

Template:STRUCTURE 1k2o

Cytochrome P450Cam with Bound BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C2-ADAMANTANE RUTHENIUM (II)


Overview

Cytochromes P450 play key roles in drug metabolism and disease by oxidizing a wide variety of natural and xenobiotic compounds. High-resolution crystal structures of P450cam bound to ruthenium sensitizer-linked substrates reveal an open conformation of the enzyme that allows substrates to access the active center via a 22-A deep channel. Interactions of alkyl and fluorinated biphenyl linkers with the channel demonstrate the importance of exploiting protein dynamics for specific inhibitor design. Large changes in peripheral enzyme structure (F and G helices) couple to conformational changes in active center residues (I helix) implicated in proton pumping and dioxygen activation. Common conformational states among P450cam and homologous enzymes indicate that static and dynamic variability in the F/G helix region allows the 54 human P450s to oxidize thousands of substrates.

About this Structure

1K2O is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Probing the open state of cytochrome P450cam with ruthenium-linker substrates., Dunn AR, Dmochowski IJ, Bilwes AM, Gray HB, Crane BR, Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12420-5. Epub 2001 Oct 16. PMID:11606730 Page seeded by OCA on Fri May 2 22:13:42 2008

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