4r5u

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==Crystal structure of Rhodostomin R46E mutant==
==Crystal structure of Rhodostomin R46E mutant==
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<StructureSection load='4r5u' size='340' side='right' caption='[[4r5u]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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<StructureSection load='4r5u' size='340' side='right'caption='[[4r5u]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agkistrodon_rhodostoma Agkistrodon rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5U FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5r|4r5r]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5u OCA], [https://pdbe.org/4r5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5u RCSB], [https://www.ebi.ac.uk/pdbsum/4r5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5u ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Agkistrodon rhodostoma])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5u OCA], [http://pdbe.org/4r5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r5u RCSB], [http://www.ebi.ac.uk/pdbsum/4r5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5u ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
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[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
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==See Also==
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*[[Disintegrin|Disintegrin]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Agkistrodon rhodostoma]]
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[[Category: Calloselasma rhodostoma]]
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[[Category: Chang, Y T]]
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[[Category: Large Structures]]
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[[Category: Chuang, W J]]
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[[Category: Chang YT]]
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[[Category: Huang, C H]]
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[[Category: Chuang WJ]]
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[[Category: Jeng, W Y]]
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[[Category: Huang CH]]
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[[Category: Shiu, J H]]
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[[Category: Jeng WY]]
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[[Category: Disintegrin]]
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[[Category: Shiu JH]]
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[[Category: Integrin]]
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[[Category: Linker region]]
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[[Category: Rgd motif]]
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[[Category: Rhodostomin]]
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[[Category: Toxin]]
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Revision as of 06:41, 2 March 2023

Crystal structure of Rhodostomin R46E mutant

PDB ID 4r5u

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