1k2p

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[[Image:1k2p.jpg|left|200px]]
[[Image:1k2p.jpg|left|200px]]
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{{Structure
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|PDB= 1k2p |SIZE=350|CAPTION= <scene name='initialview01'>1k2p</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1k2p", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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{{STRUCTURE_1k2p| PDB=1k2p | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2p OCA], [http://www.ebi.ac.uk/pdbsum/1k2p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k2p RCSB]</span>
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'''Crystal structure of Bruton's tyrosine kinase domain'''
'''Crystal structure of Bruton's tyrosine kinase domain'''
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[[Category: Uckun, F M.]]
[[Category: Uckun, F M.]]
[[Category: Zhou, M.]]
[[Category: Zhou, M.]]
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[[Category: bruton tryosine kinase]]
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[[Category: Bruton tryosine kinase]]
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[[Category: kinase domain]]
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[[Category: Kinase domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:13:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:42:32 2008''
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Revision as of 19:13, 2 May 2008

Image:1k2p.jpg

Template:STRUCTURE 1k2p

Crystal structure of Bruton's tyrosine kinase domain


Overview

Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 A resolution. A comparison with the structures of other tyrosine kinases and a possible mechanism of activation unique to Bruton's tyrosine kinase are provided.

About this Structure

1K2P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia., Mao C, Zhou M, Uckun FM, J Biol Chem. 2001 Nov 2;276(44):41435-43. Epub 2001 Aug 29. PMID:11527964 Page seeded by OCA on Fri May 2 22:13:45 2008

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