4rdo

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<StructureSection load='4rdo' size='340' side='right'caption='[[4rdo]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='4rdo' size='340' side='right'caption='[[4rdo]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rdo]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RDO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RDO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rdo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RDO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rdn|4rdn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rdo OCA], [https://pdbe.org/4rdo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rdo RCSB], [https://www.ebi.ac.uk/pdbsum/4rdo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rdo ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YTHDF2, HGRG8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rdo OCA], [http://pdbe.org/4rdo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rdo RCSB], [http://www.ebi.ac.uk/pdbsum/4rdo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rdo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN]] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref>
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[https://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, F D]]
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[[Category: Li FD]]
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[[Category: Shi, Y Y]]
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[[Category: Shi YY]]
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[[Category: Wu, J H]]
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[[Category: Wu JH]]
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[[Category: Zhao, D B]]
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[[Category: Zhao DB]]
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[[Category: Atypical beta-propeller]]
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[[Category: M6a methylated rna]]
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[[Category: Rna binding]]
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[[Category: Rna binding protein]]
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Revision as of 06:50, 2 March 2023

Structure of YTH-YTHDF2 in the free state

PDB ID 4rdo

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