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| | <StructureSection load='4rhr' size='340' side='right'caption='[[4rhr]], [[Resolution|resolution]] 2.08Å' scene=''> | | <StructureSection load='4rhr' size='340' side='right'caption='[[4rhr]], [[Resolution|resolution]] 2.08Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4rhr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhi"_schroeter_1886 "bacillus typhi" schroeter 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4rhr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi Salmonella enterica subsp. enterica serovar Typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RHR FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k6l|4k6l]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhr OCA], [https://pdbe.org/4rhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhr RCSB], [https://www.ebi.ac.uk/pdbsum/4rhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhr ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STY1891, t1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhr OCA], [http://pdbe.org/4rhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rhr RCSB], [http://www.ebi.ac.uk/pdbsum/4rhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhr ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q8Z6A3_SALTI Q8Z6A3_SALTI] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus typhi schroeter 1886]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Galan, J]] | + | [[Category: Salmonella enterica subsp. enterica serovar Typhi]] |
| - | [[Category: Gao, X]] | + | [[Category: Galan J]] |
| - | [[Category: Wang, J]]
| + | [[Category: Gao X]] |
| - | [[Category: Sugar]] | + | [[Category: Wang J]] |
| - | [[Category: Sugar binding]] | + | |
| - | [[Category: Sugar binding motif]]
| + | |
| - | [[Category: Sugar binding protein]]
| + | |
| Structural highlights
Function
Q8Z6A3_SALTI
Publication Abstract from PubMed
Salmonella Typhi is an exclusive human pathogen that causes typhoid fever. Typhoid toxin is a S. Typhi virulence factor that can reproduce most of the typhoid fever symptoms in experimental animals. Toxicity depends on toxin binding to terminally sialylated glycans on surface glycoproteins. Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc). Here, we report that typhoid toxin binds to and is toxic toward cells expressing glycans terminated in Neu5Ac (expressed by humans) over glycans terminated in Neu5Gc (expressed by other mammals). Mice constitutively expressing CMAH thus displaying Neu5Gc in all tissues are resistant to typhoid toxin. The atomic structure of typhoid toxin bound to Neu5Ac reveals the structural bases for its binding specificity. These findings provide insight into the molecular bases for Salmonella Typhi's host specificity and may help the development of therapies for typhoid fever.
Host adaptation of a bacterial toxin from the human pathogen salmonella typhi.,Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galan JE, Varki A Cell. 2014 Dec 4;159(6):1290-9. doi: 10.1016/j.cell.2014.10.057. PMID:25480294[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galan JE, Varki A. Host adaptation of a bacterial toxin from the human pathogen salmonella typhi. Cell. 2014 Dec 4;159(6):1290-9. doi: 10.1016/j.cell.2014.10.057. PMID:25480294 doi:http://dx.doi.org/10.1016/j.cell.2014.10.057
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