This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4rl2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4rl2' size='340' side='right'caption='[[4rl2]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='4rl2' size='340' side='right'caption='[[4rl2]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4rl2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RL2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4rl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RL2 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3S3:(1R)-2-({(R)-CARBOXY[(2R,5S)-4-CARBOXY-5-METHYL-5,6-DIHYDRO-2H-1,3-THIAZIN-2-YL]METHYL}AMINO)-2-OXO-1-PHENYLETHANAMINIUM'>3S3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3S3:(1R)-2-({(R)-CARBOXY[(2R,5S)-4-CARBOXY-5-METHYL-5,6-DIHYDRO-2H-1,3-THIAZIN-2-YL]METHYL}AMINO)-2-OXO-1-PHENYLETHANAMINIUM'>3S3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rl2 OCA], [https://pdbe.org/4rl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rl2 RCSB], [https://www.ebi.ac.uk/pdbsum/4rl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rl2 ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rl2 OCA], [http://pdbe.org/4rl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rl2 RCSB], [http://www.ebi.ac.uk/pdbsum/4rl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rl2 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
+
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Beta-lactamase]]
+
[[Category: Klebsiella pneumoniae]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ding, J]]
+
[[Category: Ding J]]
-
[[Category: Feng, H]]
+
[[Category: Feng H]]
-
[[Category: Liu, W]]
+
[[Category: Liu W]]
-
[[Category: Liu, X]]
+
[[Category: Liu X]]
-
[[Category: Wang, D C]]
+
[[Category: Wang D-C]]
-
[[Category: Xu, X]]
+
[[Category: Xu X]]
-
[[Category: Zang, S]]
+
[[Category: Zang S]]
-
[[Category: Zhang, Y]]
+
[[Category: Zhang Y]]
-
[[Category: Zhu, D]]
+
[[Category: Zhu D]]
-
[[Category: Hydrolase]]
+
-
[[Category: Ndm-1 antibiotic hydrolysis]]
+

Revision as of 07:01, 2 March 2023

Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins

PDB ID 4rl2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4rl2"
Personal tools