4rlz

From Proteopedia

(Difference between revisions)

Revision as of 07:03, 2 March 2023

Crystal structure of Norovirus OIF P domain

Structural highlights

4rlz is a 2 chain structure with sequence from Norovirus NLV/IF1998/2003/Iraq. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q6B7R3_9CALI

Publication Abstract from PubMed

Norovirus (NoV) causes epidemic acute gastroenteritis in humans, whereby histo-blood group antigens (HBGAs) play an important role in host susceptibility. Each of the two major genogroups (GI and GII) of human NoVs recognizes a unique set of HBGAs through a distinct binding interface that is conserved within a genogroup, indicating a distinct evolutionary path for each genogroup. Here, we characterize a Lewis a (Lea) antigen binding strain (OIF virus) in the GII.21 genotype that does not share the conserved GII binding interface, revealing a new evolution lineage with a distinct HBGA binding interface. Sequence alignment showed that the major residues contributing to the new HBGA binding interface are conserved among most members of the GII.21, as well as a closely related GII.13 genotype. In addition, we found that glycerol inhibits OIF binding to HBGAs, potentially allowing production of cheap antivirals against human NoVs. Taken together, our results reveal a new evolutionary lineage of NoVs selected by HBGAs, a finding that is important for understanding the diversity and widespread nature of NoVs.

A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface.,Liu W, Chen Y, Jiang X, Xia M, Yang Y, Tan M, Li X, Rao Z PLoS Pathog. 2015 Jul 6;11(7):e1005025. doi: 10.1371/journal.ppat.1005025., eCollection 2015 Jul. PMID:26147716^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Liu W, Chen Y, Jiang X, Xia M, Yang Y, Tan M, Li X, Rao Z. A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface. PLoS Pathog. 2015 Jul 6;11(7):e1005025. doi: 10.1371/journal.ppat.1005025., eCollection 2015 Jul. PMID:26147716 doi:http://dx.doi.org/10.1371/journal.ppat.1005025

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4rlz"

@@ Line 3: / Line 3: @@
 <StructureSection load='4rlz' size='340' side='right'caption='[[4rlz]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_nlv/if1998/2003/iraq Norovirus nlv/if1998/2003/iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4rlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_NLV/IF1998/2003/Iraq Norovirus NLV/IF1998/2003/Iraq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RLZ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rm0|4rm0]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [https://pdbe.org/4rlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [https://www.ebi.ac.uk/pdbsum/4rlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rlz ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rlz OCA], [http://pdbe.org/4rlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rlz RCSB], [http://www.ebi.ac.uk/pdbsum/4rlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rlz ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q6B7R3_9CALI Q6B7R3_9CALI]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 18: @@
 </div>
 <div class="pdbe-citations 4rlz" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 == References ==
 <references/>
@@ Line 22: / Line 26: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Norovirus nlv/if1998/2003/iraq]]
+[[Category: Norovirus NLV/IF1998/2003/Iraq]]
-[[Category: Chen, Y]]
+[[Category: Chen Y]]
-[[Category: Jiang, X]]
+[[Category: Jiang X]]
-[[Category: Li, X]]
+[[Category: Li X]]
-[[Category: Liu, W]]
+[[Category: Liu W]]
-[[Category: Rao, Z]]
+[[Category: Rao Z]]
-[[Category: Tan, M]]
+[[Category: Tan M]]
-[[Category: Xia, M]]
+[[Category: Xia M]]
-[[Category: Hbga]]
-[[Category: Mixed alpha/beta structure]]
-[[Category: Receptor binding]]
-[[Category: Viral protein]]
-[[Category: Virus caspid]]

4rlz

From Proteopedia

Revision as of 07:03, 2 March 2023

Crystal structure of Norovirus OIF P domain

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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