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Galactokinase

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Current revision (10:50, 7 March 2023) (edit) (undo)
 
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[[6gr2]] - hGALK + ADP + gal - human<br />
[[6gr2]] - hGALK + ADP + gal - human<br />
 +
[[7rcl]], [[7rcm]] - hGALK (mutant) + ADP + gal <br />
[[1wuu]] - hGALK + Mg + AMPPNP + gal<br />
[[1wuu]] - hGALK + Mg + AMPPNP + gal<br />
[[6q3w]], [[6q8z]] - hGALK + pyrazine derivative + gal<br />
[[6q3w]], [[6q8z]] - hGALK + pyrazine derivative + gal<br />
[[6q91]] - hGALK + benzamide derivative + gal<br />
[[6q91]] - hGALK + benzamide derivative + gal<br />
[[6q90]], [[6zgw]] - hGALK + pyridine derivative + gal<br />
[[6q90]], [[6zgw]] - hGALK + pyridine derivative + gal<br />
-
[[6q3x]], [[6zfh]] - hGALK + quinazoline derivative + gal<br />
+
[[6q3x]], [[6zfh]], [[7s49]] - hGALK + quinazoline derivative + gal<br />
-
[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]] - hGALK + pyrimidine derivative + gal<br />
+
[[6zgv]], [[6zgx]], [[6zgz]], [[6zgy]], [[6zh0]] - hGALK + pyrimidine derivative + gal<br />
 +
[[7s4c]] - hGALK (mutant) + pyrimidine derivative + gal<br />
[[6qje]] - hGALK + imidazole derivative + gal<br />
[[6qje]] - hGALK + imidazole derivative + gal<br />
 +
[[7ozx]] - hGALK + inhibitor + gal<br />
[[2aj4]] - GALK + Mg + AMPPNP + gal - yeast<br />
[[2aj4]] - GALK + Mg + AMPPNP + gal - yeast<br />
[[1s4e]] - GALK + Mg + ADP + gal - ''Pyrococcus furiosus''<br />
[[1s4e]] - GALK + Mg + ADP + gal - ''Pyrococcus furiosus''<br />

Current revision

Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code 1wuu.

Drag the structure with the mouse to rotate

References

  1. ↑ Holden HM, Thoden JB, Timson DJ, Reece RJ. Galactokinase: structure, function and role in type II galactosemia. Cell Mol Life Sci. 2004 Oct;61(19-20):2471-84. doi: 10.1007/s00018-004-4160-6. PMID:15526155 doi:http://dx.doi.org/10.1007/s00018-004-4160-6
  2. ↑ Timson DJ, Reece RJ. Functional analysis of disease-causing mutations in human galactokinase. Eur J Biochem. 2003 Apr;270(8):1767-74. PMID:12694189
  3. ↑ Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactokinase: implications for type II galactosemia. J Biol Chem. 2005 Mar 11;280(10):9662-70. Epub 2004 Dec 7. PMID:15590630 doi:10.1074/jbc.M412916200

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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