7u2m
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-desenstized state== | |
| - | + | <StructureSection load='7u2m' size='340' side='right'caption='[[7u2m]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7u2m]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U2M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=L2L:aminomethanesulfonic+acid'>L2L</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u2m OCA], [https://pdbe.org/7u2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u2m RCSB], [https://www.ebi.ac.uk/pdbsum/7u2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u2m ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLRA1_DANRE GLRA1_DANRE] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).[UniProtKB:P23415]<ref>PMID:10188956</ref> <ref>PMID:26344198</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Danio rerio]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gouaux E]] | ||
| + | [[Category: Zhu H]] | ||
Revision as of 07:26, 8 March 2023
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-desenstized state
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