7x3l

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'''Unreleased structure'''
 
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The entry 7x3l is ON HOLD until Paper Publication
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==Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044==
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<StructureSection load='7x3l' size='340' side='right'caption='[[7x3l]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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Authors: Jiang, J., Liu, Y., He, S., Chen, Y., Chu, X., Liu, Y., Guo, Q., Zhao, L., Feng, F., Liu, W., Zhang, X., Fang, P., Sun, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7x3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X3L FirstGlance]. <br>
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Description: Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8FO:(2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic+acid'>8FO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x3l OCA], [https://pdbe.org/7x3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x3l RCSB], [https://www.ebi.ac.uk/pdbsum/7x3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x3l ProSAT]</span></td></tr>
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[[Category: Guo, Q]]
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</table>
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[[Category: Zhao, L]]
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== Function ==
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[[Category: He, S]]
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[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
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[[Category: Sun, H]]
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__TOC__
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[[Category: Liu, W]]
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</StructureSection>
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[[Category: Fang, P]]
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[[Category: Homo sapiens]]
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[[Category: Feng, F]]
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[[Category: Large Structures]]
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[[Category: Liu, Y]]
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[[Category: Chen Y]]
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[[Category: Jiang, J]]
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[[Category: Chu X]]
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[[Category: Chu, X]]
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[[Category: Fang P]]
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[[Category: Chen, Y]]
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[[Category: Feng F]]
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[[Category: Zhang, X]]
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[[Category: Guo Q]]
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[[Category: He S]]
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[[Category: Jiang J]]
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[[Category: Liu W]]
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[[Category: Liu Y]]
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[[Category: Sun H]]
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[[Category: Zhang X]]
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[[Category: Zhao L]]

Revision as of 07:27, 8 March 2023

Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044

PDB ID 7x3l

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