8drn

From Proteopedia

(Difference between revisions)

Revision as of 07:34, 8 March 2023

LRRC8A:C conformation 1 (round) LRR focus 1

Structural highlights

8drn is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LRC8C_MOUSE Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215).[UniProtKB:Q8TDW0]^[1] ^[2] ^[3] ^[4]

References

↑ Tominaga K, Kondo C, Kagata T, Hishida T, Nishizuka M, Imagawa M. The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation. J Biol Chem. 2004 Aug 13;279(33):34840-8. doi: 10.1074/jbc.M312927200. Epub 2004 , Jun 7. PMID:15184384 doi:http://dx.doi.org/10.1074/jbc.M312927200
↑ Tominaga K, Johmura Y, Nishizuka M, Imagawa M. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. J Cell Sci. 2004 Dec 1;117(Pt 25):6217-26. PMID:15564382 doi:http://dx.doi.org/117/25/6217
↑ Hayashi T, Nozaki Y, Nishizuka M, Ikawa M, Osada S, Imagawa M. Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet. Biol Pharm Bull. 2011;34(8):1257-63. doi: 10.1248/bpb.34.1257. PMID:21804215 doi:http://dx.doi.org/10.1248/bpb.34.1257
↑ Deneka D, Sawicka M, Lam AKM, Paulino C, Dutzler R. Structure of a volume-regulated anion channel of the LRRC8 family. Nature. 2018 May 16. pii: 10.1038/s41586-018-0134-y. doi:, 10.1038/s41586-018-0134-y. PMID:29769723 doi:http://dx.doi.org/10.1038/s41586-018-0134-y

1 Structural highlights
2 Function
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8drn"

Categories: Large Structures | Mus musculus | Brohawn SG | Kern DM

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8drn is ON HOLD
+==LRRC8A:C conformation 1 (round) LRR focus 1==
+<StructureSection load='8drn' size='340' side='right'caption='[[8drn]], [[Resolution|resolution]] 4.12&Aring;' scene=''>
-Authors: Kern, D.M., Brohawn, S.G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8drn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DRN FirstGlance]. <br>
-Description: LRRC8A:C conformation 1 (round) LRR focus 1
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8drn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drn OCA], [https://pdbe.org/8drn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8drn RCSB], [https://www.ebi.ac.uk/pdbsum/8drn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8drn ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Brohawn, S.G]]
+== Function ==
-[[Category: Kern, D.M]]
+[https://www.uniprot.org/uniprot/LRC8C_MOUSE LRC8C_MOUSE] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215).[UniProtKB:Q8TDW0]<ref>PMID:15184384</ref> <ref>PMID:15564382</ref> <ref>PMID:21804215</ref> <ref>PMID:29769723</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Brohawn SG]]
+[[Category: Kern DM]]

8drn

From Proteopedia

Revision as of 07:34, 8 March 2023

LRRC8A:C conformation 1 (round) LRR focus 1

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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