8fra

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m (Protected "8fra" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8fra is ON HOLD
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==Mouse acidic mammalian chitinase, catalytic domain in complex with diacetylchitobiose at pH 5.60==
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<StructureSection load='8fra' size='340' side='right'caption='[[8fra]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors: Diaz, R.E., Fraser, J.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fra]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FRA FirstGlance]. <br>
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Description: Mouse acidic mammalian chitinase, catalytic domain in complex with diacetylchitobiose at pH 5.60
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fra OCA], [https://pdbe.org/8fra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fra RCSB], [https://www.ebi.ac.uk/pdbsum/8fra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fra ProSAT]</span></td></tr>
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[[Category: Diaz, R.E]]
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</table>
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[[Category: Fraser, J.S]]
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== Function ==
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[https://www.uniprot.org/uniprot/CHIA_MOUSE CHIA_MOUSE] Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme.<ref>PMID:11085997</ref> <ref>PMID:12133911</ref> <ref>PMID:15192232</ref> <ref>PMID:19076793</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Diaz RE]]
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[[Category: Fraser JS]]

Revision as of 07:37, 8 March 2023

Mouse acidic mammalian chitinase, catalytic domain in complex with diacetylchitobiose at pH 5.60

PDB ID 8fra

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