2bsy
From Proteopedia
(Difference between revisions)
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<StructureSection load='2bsy' size='340' side='right'caption='[[2bsy]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2bsy' size='340' side='right'caption='[[2bsy]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2bsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2bsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BSY FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bt1|2bt1]]</div></td></tr> | ||
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bsy OCA], [https://pdbe.org/2bsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bsy RCSB], [https://www.ebi.ac.uk/pdbsum/2bsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bsy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bsy OCA], [https://pdbe.org/2bsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bsy RCSB], [https://www.ebi.ac.uk/pdbsum/2bsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bsy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DUT_EBVB9 DUT_EBVB9] Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into DNA. Induces immune dysregulation that contributes to the pathophysiology of the virus infection. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human gammaherpesvirus 4]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Buisson M]] | |
| - | [[Category: Buisson | + | [[Category: Burmeister WP]] |
| - | [[Category: Burmeister | + | [[Category: Cusack S]] |
| - | [[Category: Cusack | + | [[Category: Seigneurin J-M]] |
| - | [[Category: Seigneurin | + | [[Category: Tarbouriech N]] |
| - | [[Category: Tarbouriech | + | |
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Revision as of 07:38, 8 March 2023
Epstein Barr Virus dUTPase
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