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1k4c

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[[Image:1k4c.gif|left|200px]]
[[Image:1k4c.gif|left|200px]]
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{{Structure
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|PDB= 1k4c |SIZE=350|CAPTION= <scene name='initialview01'>1k4c</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1k4c", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4c OCA], [http://www.ebi.ac.uk/pdbsum/1k4c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k4c RCSB]</span>
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'''Potassium Channel KcsA-Fab complex in high concentration of K+'''
'''Potassium Channel KcsA-Fab complex in high concentration of K+'''
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[[Category: Morais-Cabral, J H.]]
[[Category: Morais-Cabral, J H.]]
[[Category: Zhou, Y.]]
[[Category: Zhou, Y.]]
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[[Category: k channel]]
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[[Category: K channel]]
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[[Category: protein-antibody fab complex]]
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[[Category: Protein-antibody fab complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:17:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:13 2008''
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Revision as of 19:17, 2 May 2008

Image:1k4c.gif


PDB ID 1k4c

Drag the structure with the mouse to rotate
1k4c, resolution 2.00Å ()
Ligands: , ,
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Potassium Channel KcsA-Fab complex in high concentration of K+


Overview

Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge. To discover how the K+ channel solves this fundamental aspect of ion conduction, we solved the structure of the KcsA K+ channel in complex with a monoclonal Fab antibody fragment at 2.0 A resolution. Here we show how the K+ channel displaces water molecules around an ion at its extracellular entryway, and how it holds a K+ ion in a square antiprism of water molecules in a cavity near its intracellular entryway. Carbonyl oxygen atoms within the selectivity filter form a very similar square antiprism around each K+ binding site, as if to mimic the waters of hydration. The selectivity filter changes its ion coordination structure in low K+ solutions. This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating.

About this Structure

1K4C is a Single protein structure of sequence from Mus musculus and Streptomyces lividans. The following page contains interesting information on the relation of 1K4C with [Potassium Channels]. Full crystallographic information is available from OCA.

Reference

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution., Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R, Nature. 2001 Nov 1;414(6859):43-8. PMID:11689936 Page seeded by OCA on Fri May 2 22:17:28 2008

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