2mho

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==Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide==
==Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide==
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<StructureSection load='2mho' size='340' side='right'caption='[[2mho]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mho' size='340' side='right'caption='[[2mho]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHO FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dlg4, Dlgh4, Psd95 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mho OCA], [https://pdbe.org/2mho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mho RCSB], [https://www.ebi.ac.uk/pdbsum/2mho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mho ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mho OCA], [https://pdbe.org/2mho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mho RCSB], [https://www.ebi.ac.uk/pdbsum/2mho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mho ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> [[https://www.uniprot.org/uniprot/5HT2C_RAT 5HT2C_RAT]] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.<ref>PMID:3399891</ref>
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[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
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==See Also==
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dorr, L A]]
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[[Category: Rattus norvegicus]]
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[[Category: Lian, L]]
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[[Category: Dorr LA]]
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[[Category: Phelan, M M]]
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[[Category: Lian L]]
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[[Category: 5-hydroxytryptamine receptor fragment]]
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[[Category: Phelan MM]]
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[[Category: Pdz]]
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[[Category: Protein binding]]
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[[Category: Psd-95]]
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Revision as of 07:58, 8 March 2023

Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide

PDB ID 2mho

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