This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1j1b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1j1b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j1b, resolution 1.8&Aring;" /> '''Binary complex struc...)
Next diff →

Revision as of 15:29, 12 November 2007

Image:1j1b.gif

1j1b, resolution 1.8Å

Drag the structure with the mouse to rotate

Binary complex structure of human tau protein kinase I with AMPPNP

Overview

Human tau-protein kinase I (TPK I; also known as glycogen synthase kinase, 3 beta; GSK3 beta) is a serine/threonine protein kinase that participates, in Alzheimer's disease. Here, binary complex structures of full-length TPK, I/GSK3 beta with the ATP analogues ADP and AMPPNP solved by the X-ray, diffraction method at 2.1 and 1.8 A resolution, respectively, are, reported. TPK I/GSK3 beta is composed of three domains: an N-terminal, domain consisting of a closed beta-barrel structure, a C-terminal domain, containing a 'kinase fold' structure and a small extra-domain subsequent, to the C-terminal domain. The catalytic site is between the two major, domains and has an ATP-analogue molecule in its ATP-binding site. The, adenine ring is buried in the hydrophobic pocket and interacts, specifically with the main-chain atoms of the hinge loop. The overall, structure and substrate-binding residues are similar to those observed in, other Ser/Thr protein kinases, while Arg141 (which is not conserved among, other Ser/Thr protein kinases) is one of the key residues for specific, ATP/ADP recognition by TPK I/GSK3 beta. No residues are phosphorylated, while the orientation of the activation loop in TPK I/GSK3 beta is similar, to that in phosphorylated CDK2 and ERK2, suggesting that TPK I/GSK3 beta, falls into a conformation that enables it to be constitutively active.

About this Structure

1J1B is a Single protein structure of sequence from Homo sapiens with ANP as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.

Reference

Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta., Aoki M, Yokota T, Sugiura I, Sasaki C, Hasegawa T, Okumura C, Ishiguro K, Kohno T, Sugio S, Matsuzaki T, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):439-46. Epub 2004, Feb 25. PMID:14993667

Page seeded by OCA on Mon Nov 12 17:36:23 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1j1b"
Personal tools