2mx6
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Complex structure of Dvl PDZ domain with ligand== | ==Complex structure of Dvl PDZ domain with ligand== | ||
| - | <StructureSection load='2mx6' size='340' side='right'caption='[[2mx6 | + | <StructureSection load='2mx6' size='340' side='right'caption='[[2mx6]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2mx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MX6 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mx6 OCA], [https://pdbe.org/2mx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mx6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mx6 OCA], [https://pdbe.org/2mx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mx6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mx6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 15: | Line 14: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Zhang X]] |
| - | [[Category: | + | [[Category: Zheng JJ]] |
| - | + | ||
| - | + | ||
Revision as of 08:10, 8 March 2023
Complex structure of Dvl PDZ domain with ligand
| |||||||||||
