2n3a

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==Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404)==
==Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404)==
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<StructureSection load='2n3a' size='340' side='right'caption='[[2n3a]], [[NMR_Ensembles_of_Models | 29 NMR models]]' scene=''>
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<StructureSection load='2n3a' size='340' side='right'caption='[[2n3a]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3A FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PSIP1, DFS70, LEDGF, PSIP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3a OCA], [https://pdbe.org/2n3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3a RCSB], [https://www.ebi.ac.uk/pdbsum/2n3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3a OCA], [https://pdbe.org/2n3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3a RCSB], [https://www.ebi.ac.uk/pdbsum/2n3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3a ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
 
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/POGZ_HUMAN POGZ_HUMAN]] Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.<ref>PMID:20562864</ref> [[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref>
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[https://www.uniprot.org/uniprot/POGZ_HUMAN POGZ_HUMAN] Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.<ref>PMID:20562864</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cermakova, K]]
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[[Category: Cermakova K]]
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[[Category: Christ, F]]
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[[Category: Christ F]]
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[[Category: Debyser, Z]]
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[[Category: De Rijck J]]
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[[Category: Demeulemeester, J]]
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[[Category: Debyser Z]]
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[[Category: Fabry, M]]
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[[Category: Demeulemeester J]]
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[[Category: Horejsi, M]]
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[[Category: Fabry M]]
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[[Category: Prochazkova, K]]
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[[Category: Horejsi M]]
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[[Category: Rezacova, P]]
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[[Category: Prochazkova K]]
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[[Category: Rijck, J De]]
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[[Category: Rezacova P]]
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[[Category: Sharma, S]]
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[[Category: Sharma S]]
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[[Category: Tesina, P]]
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[[Category: Tesina P]]
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[[Category: Veverka, V]]
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[[Category: Veverka V]]
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[[Category: H3k36me3]]
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[[Category: Ledgf/p75]]
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[[Category: Pogz]]
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[[Category: Protein binding]]
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Revision as of 08:15, 8 March 2023

Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404)

PDB ID 2n3a

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