4rwd

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==XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide==
==XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide==
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<StructureSection load='4rwd' size='340' side='right' caption='[[4rwd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4rwd' size='340' side='right'caption='[[4rwd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rwd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RWD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rwd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RWD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PRD_001256:bifunctional+peptide'>PRD_001256</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI7:2,6-DIMETHYL-L-TYROSINE'>DI7</scene>, <scene name='pdbligand=DI8:(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>DI8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwd OCA], [https://pdbe.org/4rwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rwd RCSB], [https://www.ebi.ac.uk/pdbsum/4rwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwd ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n6h|4n6h]], [[4ej4|4ej4]], [[4rwa|4rwa]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OPRD, OPRD1, cybC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwd OCA], [http://pdbe.org/4rwd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rwd RCSB], [http://www.ebi.ac.uk/pdbsum/4rwd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rwd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/OPRD_HUMAN OPRD_HUMAN] G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.<ref>PMID:22184124</ref> <ref>PMID:7808419</ref> <ref>PMID:8201839</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Ballet, S]]
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[[Category: Homo sapiens]]
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[[Category: Barty, A]]
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[[Category: Large Structures]]
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[[Category: Basu, S]]
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[[Category: Synthetic construct]]
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[[Category: Betti, C]]
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[[Category: Ballet S]]
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[[Category: Boutet, S]]
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[[Category: Barty A]]
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[[Category: Chapman, H N]]
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[[Category: Basu S]]
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[[Category: Cherezov, V]]
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[[Category: Betti C]]
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[[Category: Coe, J]]
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[[Category: Boutet S]]
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[[Category: Conrad, C E]]
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[[Category: Chapman HN]]
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[[Category: Fenalti, G]]
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[[Category: Cherezov V]]
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[[Category: Fromme, P]]
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[[Category: Coe J]]
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[[Category: Fromme, R]]
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[[Category: Conrad CE]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Fenalti G]]
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[[Category: Gati, C]]
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[[Category: Fromme P]]
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[[Category: Giguere, P]]
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[[Category: Fromme R]]
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[[Category: Guillemyn, K]]
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[[Category: Gati C]]
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[[Category: Han, G W]]
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[[Category: Giguere P]]
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[[Category: Ishchenko, A]]
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[[Category: Guillemyn K]]
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[[Category: James, D]]
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[[Category: Han GW]]
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[[Category: Katritch, V]]
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[[Category: Ishchenko A]]
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[[Category: Liu, W]]
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[[Category: James D]]
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[[Category: Messerschmidt, M]]
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[[Category: Katritch V]]
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[[Category: Metz, M]]
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[[Category: Liu W]]
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[[Category: Oberthuer, D]]
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[[Category: Messerschmidt M]]
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[[Category: Roth, B L]]
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[[Category: Metz M]]
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[[Category: Schiller, P W]]
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[[Category: Oberthuer D]]
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[[Category: Spence, J C.H]]
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[[Category: Roth BL]]
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[[Category: Stevens, R C]]
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[[Category: Schiller PW]]
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[[Category: Tourwe, D]]
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[[Category: Spence JCH]]
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[[Category: Wang, D]]
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[[Category: Stevens RC]]
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[[Category: Weierstall, U]]
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[[Category: Tourwe D]]
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[[Category: White, T A]]
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[[Category: Wang D]]
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[[Category: Williams, G J]]
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[[Category: Weierstall U]]
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[[Category: Yefanov, O M]]
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[[Category: White TA]]
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[[Category: Yoon, C H]]
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[[Category: Williams GJ]]
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[[Category: Zatsepin, N A]]
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[[Category: Yefanov OM]]
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[[Category: Zhang, H]]
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[[Category: Yoon CH]]
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[[Category: Bifunctional peptide]]
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[[Category: Zatsepin NA]]
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[[Category: Bril]]
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[[Category: Zhang H]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Gpcr signaling]]
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[[Category: Human opioid receptor]]
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[[Category: Lipidic cubic phase]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Psi-biology]]
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[[Category: Serial femtosecond crystallography]]
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[[Category: Structural genomic]]
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[[Category: X-ray free-electron laser]]
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Revision as of 08:31, 8 March 2023

XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide

PDB ID 4rwd

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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