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Sandbox Reserved 1777

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USE THE ROCK BUT CHANGE HOW FAR IT ROCKS TO
USE THE ROCK BUT CHANGE HOW FAR IT ROCKS TO
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Switch I and II are located on MRAS. The switches determine whether MRAS can bind to SHOC2-PP1C. The switches have to go through a [https://en.wikipedia.org/wiki/Conformational_change. conformational change] to allow binding of SHOC2-PP1C to MRAS. This conformational change is caused by GTP replacing GDP. Once GTP is added MRAS shifts and binds with SHOC2. When GDP is bound to MRAS switch II is moved outward which causes a steric clash with SHOC2. When GTP is bound, switch II can form various hydrophobic interactions with SHOC2. Interactions are strengthened with [https://en.wikipedia.org/wiki/Hydrogen_bond]][[hydrogen bonding. hydrogen bonding] and [https://en.wikipedia.org/wiki/Stacking_(chemistry)]][[pi stacking. pi stacking]. When MRAS is bound to SHOC2-PP1C, switch I has an important role in making interactions with PP1C.
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Switch I and II are located on MRAS. The switches determine whether MRAS can bind to SHOC2-PP1C. The switches have to go through a [https://en.wikipedia.org/wiki/Conformational_change. conformational change] to allow binding of SHOC2-PP1C to MRAS. This conformational change is caused by GTP replacing GDP. Once GTP is added MRAS shifts and binds with SHOC2. When GDP is bound to MRAS switch II is moved outward which causes a steric clash with SHOC2. When GTP is bound, switch II can form various hydrophobic interactions with SHOC2. Interactions are strengthened with [https://en.wikipedia.org/wiki/Hydrogen_bond. hydrogen bonding] and [https://en.wikipedia.org/wiki/Stacking_(chemistry). pi stacking]. When MRAS is bound to SHOC2-PP1C, switch I has an important role in making interactions with PP1C.
== Disease ==
== Disease ==

Revision as of 02:27, 15 March 2023

This Sandbox is Reserved from February 27 through August 31, 2023 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1765 through Sandbox Reserved 1795.
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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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