1k64

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[[Image:1k64.jpg|left|200px]]
[[Image:1k64.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1k64", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>
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{{STRUCTURE_1k64| PDB=1k64 | SCENE= }}
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|RELATEDENTRY=[[1plp|1PLP]], [[1qs3|1QS3]], [[1dg2|1DG2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k64 OCA], [http://www.ebi.ac.uk/pdbsum/1k64 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k64 RCSB]</span>
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'''NMR Structue of alpha-conotoxin EI'''
'''NMR Structue of alpha-conotoxin EI'''
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==About this Structure==
==About this Structure==
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1K64 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K64 OCA].
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1K64 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K64 OCA].
==Reference==
==Reference==
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[[Category: Park, K H.]]
[[Category: Park, K H.]]
[[Category: Suk, J E.]]
[[Category: Suk, J E.]]
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[[Category: omega-shaped containing a-helix]]
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[[Category: Omega-shaped containing a-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:57 2008''
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Revision as of 19:21, 2 May 2008

Image:1k64.jpg

Template:STRUCTURE 1k64

NMR Structue of alpha-conotoxin EI


Overview

A high resolution structure of alpha-conotoxin EI has been determined by (1)H NMR spectroscopy and molecular modeling. alpha-Conotoxin EI has the same disulfide framework as alpha 4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the neuromuscular receptor as do the alpha 3/5 and alpha A conotoxins. The unique binding preference of alpha-conotoxin EI to the alpha(1)/delta subunit interface of Torpedo neuromuscular receptor makes it a valuable structural template for superposition of various alpha-conotoxins possessing distinct receptor subtype specificities. Structural comparison of alpha-conotoxin EI with the gamma-subunit favoring alpha-conotoxin GI suggests that the Torpedo delta-subunit preference of the former originates from its second loop. Superposition of three-dimensional structures of seven alpha-conotoxins reveals that the estimated size of the toxin-binding pocket in nicotinic acetylcholine receptor is approximately 20 A (height) x 20 A (width) x 15 A (thickness).

About this Structure

1K64 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor., Park KH, Suk JE, Jacobsen R, Gray WR, McIntosh JM, Han KH, J Biol Chem. 2001 Dec 28;276(52):49028-33. Epub 2001 Oct 18. PMID:11641403 Page seeded by OCA on Fri May 2 22:21:17 2008

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