7txt
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl== | |
| - | + | <StructureSection load='7txt' size='340' side='right'caption='[[7txt]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7txt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TXT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KWC:1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine'>KWC</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7txt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7txt OCA], [https://pdbe.org/7txt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7txt RCSB], [https://www.ebi.ac.uk/pdbsum/7txt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7txt ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Basbaum AI]] | ||
| + | [[Category: Bekele B]] | ||
| + | [[Category: Billesboelle CB]] | ||
| + | [[Category: Boytsov D]] | ||
| + | [[Category: Braz J]] | ||
| + | [[Category: Craik V]] | ||
| + | [[Category: Huang XP]] | ||
| + | [[Category: Lak P]] | ||
| + | [[Category: Manglik A]] | ||
| + | [[Category: O'Donnell H]] | ||
| + | [[Category: Rodriguiz RM]] | ||
| + | [[Category: Roth BL]] | ||
| + | [[Category: Roy K]] | ||
| + | [[Category: Rudnick G]] | ||
| + | [[Category: Sandtner W]] | ||
| + | [[Category: Seth A]] | ||
| + | [[Category: Shoichet BK]] | ||
| + | [[Category: Singh I]] | ||
| + | [[Category: Wetsel WC]] | ||
Revision as of 09:47, 15 March 2023
Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl
| |||||||||||
Categories: Homo sapiens | Large Structures | Mus musculus | Basbaum AI | Bekele B | Billesboelle CB | Boytsov D | Braz J | Craik V | Huang XP | Lak P | Manglik A | O'Donnell H | Rodriguiz RM | Roth BL | Roy K | Rudnick G | Sandtner W | Seth A | Shoichet BK | Singh I | Wetsel WC
