1k6y
From Proteopedia
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'''Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase''' | '''Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase''' | ||
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[[Category: Wang, J.]] | [[Category: Wang, J.]] | ||
[[Category: Yang, W.]] | [[Category: Yang, W.]] | ||
| - | [[Category: | + | [[Category: Domain organization]] |
| - | [[Category: | + | [[Category: Hiv-1]] |
| - | [[Category: | + | [[Category: Integrase]] |
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Revision as of 19:22, 2 May 2008
Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase
Overview
Retroviral integrase, an essential enzyme for replication of human immunodeficiency virus type-1 (HIV-1) and other retroviruses, contains three structurally distinct domains, an N-terminal domain, the catalytic core and a C-terminal domain. To elucidate their spatial arrangement, we have solved the structure of a fragment of HIV-1 integrase comprising the N-terminal and catalytic core domains. This structure reveals a dimer interface between the N-terminal domains different from that observed for the isolated domain. It also complements the previously determined structure of the C-terminal two domains of HIV-1 integrase; superposition of the conserved catalytic core of the two structures results in a plausible full-length integrase dimer. Furthermore, an integrase tetramer formed by crystal lattice contacts bears structural resemblance to a related bacterial transposase, Tn5, and exhibits positively charged channels suitable for DNA binding.
About this Structure
1K6Y is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein., Wang JY, Ling H, Yang W, Craigie R, EMBO J. 2001 Dec 17;20(24):7333-43. PMID:11743009 Page seeded by OCA on Fri May 2 22:22:57 2008
