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7ler
From Proteopedia
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==Netrin-1 filament assembly== | ==Netrin-1 filament assembly== | ||
| - | <StructureSection load='7ler' size='340' side='right'caption='[[7ler]]' scene=''> | + | <StructureSection load='7ler' size='340' side='right'caption='[[7ler]], [[Resolution|resolution]] 5.99Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LER FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ler]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LER FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ler FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ler OCA], [https://pdbe.org/7ler PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ler RCSB], [https://www.ebi.ac.uk/pdbsum/7ler PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ler ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ler FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ler OCA], [https://pdbe.org/7ler PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ler RCSB], [https://www.ebi.ac.uk/pdbsum/7ler PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ler ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NET1_CHICK NET1_CHICK] Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular processes including axon pathfinding, cell migration, adhesion, differentiation, and survival. Here, we present a molecular understanding of netrin-1 mediated interactions with glycosaminoglycan chains of diverse heparan sulfate proteoglycans (HSPGs) and short heparin oligosaccharides. Whereas interactions with HSPGs act as platform to co-localise netrin-1 close to the cell surface, heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1. Remarkably, the monomer-dimer equilibrium of netrin-1 in solution is abolished in the presence of heparin oligosaccharides and replaced with highly hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation. In our integrated approach we provide a molecular mechanism for the filament assembly which opens fresh paths towards a molecular understanding of netrin-1 functions. | ||
| + | |||
| + | The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.,Meier M, Gupta M, Akgul S, McDougall M, Imhof T, Nikodemus D, Reuten R, Moya-Torres A, To V, Ferens F, Heide F, Padilla-Meier GP, Kukura P, Huang W, Gerisch B, Morgelin M, Poole K, Antebi A, Koch M, Stetefeld J Nat Commun. 2023 Mar 3;14(1):1226. doi: 10.1038/s41467-023-36692-w. PMID:36869049<ref>PMID:36869049</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ler" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Gallus gallus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gupta M]] | [[Category: Gupta M]] | ||
[[Category: McDougall M]] | [[Category: McDougall M]] | ||
[[Category: Stetefeld J]] | [[Category: Stetefeld J]] | ||
Revision as of 09:59, 15 March 2023
Netrin-1 filament assembly
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