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2n7k

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==Unveiling the structural determinants of KIAA0323 binding preference for NEDD8==
==Unveiling the structural determinants of KIAA0323 binding preference for NEDD8==
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<StructureSection load='2n7k' size='340' side='right'caption='[[2n7k]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''>
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<StructureSection load='2n7k' size='340' side='right'caption='[[2n7k]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7K FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NEDD8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KHNYN, KIAA0323 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7k OCA], [https://pdbe.org/2n7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7k RCSB], [https://www.ebi.ac.uk/pdbsum/2n7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7k ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7k OCA], [https://pdbe.org/2n7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7k RCSB], [https://www.ebi.ac.uk/pdbsum/2n7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7k ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NEDD8_HUMAN NEDD8_HUMAN]] Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.<ref>PMID:10318914</ref> <ref>PMID:10597293</ref> <ref>PMID:11953428</ref>
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[https://www.uniprot.org/uniprot/NEDD8_HUMAN NEDD8_HUMAN] Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.<ref>PMID:10318914</ref> <ref>PMID:10597293</ref> <ref>PMID:11953428</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Castagnoli, L]]
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[[Category: Castagnoli L]]
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[[Category: Cesareni, G]]
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[[Category: Cesareni G]]
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[[Category: Iannuccelli, M]]
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[[Category: Iannuccelli M]]
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[[Category: Mandaliti, W]]
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[[Category: Mandaliti W]]
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[[Category: Mattioni, A]]
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[[Category: Mattioni A]]
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[[Category: Nepravishta, R]]
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[[Category: Nepravishta R]]
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[[Category: Paci, M]]
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[[Category: Paci M]]
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[[Category: Polo, S]]
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[[Category: Polo S]]
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[[Category: Procopio, R]]
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[[Category: Procopio R]]
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[[Category: Santonico, E]]
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[[Category: Santonico E]]
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[[Category: Valentini, E]]
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[[Category: Valentini E]]
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[[Category: Signaling protein]]
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Revision as of 10:22, 15 March 2023

Unveiling the structural determinants of KIAA0323 binding preference for NEDD8

PDB ID 2n7k

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