1k79

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1k79.gif|left|200px]]
[[Image:1k79.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1k79 |SIZE=350|CAPTION= <scene name='initialview01'>1k79</scene>, resolution 2.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_1k79", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Ets-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1k79| PDB=1k79 | SCENE= }}
-
|RELATEDENTRY=[[1k78|1K78]], [[1k7a|1K7A]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k79 OCA], [http://www.ebi.ac.uk/pdbsum/1k79 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k79 RCSB]</span>
+
-
}}
+
'''Ets-1(331-440)+GGAA duplex'''
'''Ets-1(331-440)+GGAA duplex'''
Line 28: Line 25:
[[Category: Hagman, J.]]
[[Category: Hagman, J.]]
[[Category: Wolberger, C.]]
[[Category: Wolberger, C.]]
-
[[Category: ets domain]]
+
[[Category: Ets domain]]
-
[[Category: transcription factor]]
+
[[Category: Transcription factor]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:23:36 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:26 2008''
+

Revision as of 19:23, 2 May 2008

Image:1k79.gif

Template:STRUCTURE 1k79

Ets-1(331-440)+GGAA duplex


Overview

Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.

About this Structure

1K79 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502 Page seeded by OCA on Fri May 2 22:23:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k79"
Personal tools