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4rye

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==The crystal structure of D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium tuberculosis H37Rv==
==The crystal structure of D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium tuberculosis H37Rv==
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<StructureSection load='4rye' size='340' side='right' caption='[[4rye]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4rye' size='340' side='right'caption='[[4rye]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rye]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RYE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rye]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RYE FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dacB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rye OCA], [https://pdbe.org/4rye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rye RCSB], [https://www.ebi.ac.uk/pdbsum/4rye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rye ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rye OCA], [http://pdbe.org/4rye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rye RCSB], [http://www.ebi.ac.uk/pdbsum/4rye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rye ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DACB2_MYCTU DACB2_MYCTU] Probably cleaves the terminal D-Ala-D-Ala dipeptide of the peptidoglycan stem peptide (Probable). Shows significant D,D-carboxypeptidase activity in vitro (PubMed:22906310). Acts on the synthetic penta-peptide substrate Penta-DAP (L-Ala-gamma-D-Gln-DAP-D-Ala-D-Ala). Shows also weak activity on Penta-Lys (L-Ala-gamma-Glu-L-Lys-D-Ala-D-Ala) (PubMed:22906310). The catalytic domain binds weakly to peptidoglycan in vitro (PubMed:25551456). Plays an important role in the maintenance of colony morphology and cell wall permeability and integrity (PubMed:25467937).<ref>PMID:22906310</ref> <ref>PMID:25467937</ref> <ref>PMID:25551456</ref> <ref>PMID:22906310</ref>
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==See Also==
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Cuff, M]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Hatzos-Skintges, C]]
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[[Category: Cuff M]]
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[[Category: Jedrzejczak, R]]
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[[Category: Hatzos-Skintges C]]
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[[Category: Joachimiak, A]]
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[[Category: Jedrzejczak R]]
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[[Category: Structural genomic]]
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[[Category: Joachimiak A]]
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[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
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[[Category: Sacchettini J]]
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[[Category: Sacchettini, J]]
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[[Category: Tan K]]
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[[Category: Tan, K]]
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[[Category: Hydrolase]]
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[[Category: Mcsg]]
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[[Category: Mtbi]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]
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Current revision

The crystal structure of D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium tuberculosis H37Rv

PDB ID 4rye

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