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4ryl

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==Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea==
==Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea==
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<StructureSection load='4ryl' size='340' side='right' caption='[[4ryl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4ryl' size='340' side='right'caption='[[4ryl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ryl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RYL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ryl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RYL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZG:1-ISOQUINOLIN-6-YL-3-[2-OXO-2-(PYRROLIDIN-1-YL)ETHYL]UREA'>3ZG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ZG:1-ISOQUINOLIN-6-YL-3-[2-OXO-2-(PYRROLIDIN-1-YL)ETHYL]UREA'>3ZG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRMT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ryl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ryl OCA], [https://pdbe.org/4ryl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ryl RCSB], [https://www.ebi.ac.uk/pdbsum/4ryl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ryl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ryl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ryl OCA], [http://pdbe.org/4ryl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ryl RCSB], [http://www.ebi.ac.uk/pdbsum/4ryl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ryl ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANM3_HUMAN ANM3_HUMAN] Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Atadja, P]]
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[[Category: Arrowsmith CH]]
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[[Category: Barsyte-Lovejoy, D]]
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[[Category: Atadja P]]
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[[Category: Bountra, C]]
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[[Category: Barsyte-Lovejoy D]]
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[[Category: Brown, P J]]
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[[Category: Bountra C]]
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[[Category: Dai, M]]
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[[Category: Brown PJ]]
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[[Category: Dobrovetsky, E]]
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[[Category: Dai M]]
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[[Category: Dong, A]]
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[[Category: Dobrovetsky E]]
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[[Category: Edwards, A M]]
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[[Category: Dong A]]
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[[Category: Eram, M S]]
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[[Category: Edwards AM]]
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[[Category: He, F]]
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[[Category: Eram MS]]
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[[Category: Huang, X P]]
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[[Category: He F]]
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[[Category: Jin, J]]
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[[Category: Huang XP]]
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[[Category: Kaniskan, H U]]
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[[Category: Jin J]]
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[[Category: Kennedy, S]]
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[[Category: Kaniskan HU]]
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[[Category: Landon, M]]
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[[Category: Kennedy S]]
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[[Category: Li, F]]
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[[Category: Landon M]]
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[[Category: Lin, Y]]
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[[Category: Li F]]
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[[Category: Lin-Jones, J]]
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[[Category: Lin Y]]
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[[Category: Luo, X]]
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[[Category: Lin-Jones J]]
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[[Category: Min, S J]]
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[[Category: Luo X]]
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[[Category: Roth, B L]]
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[[Category: Min SJ]]
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[[Category: Structural genomic]]
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[[Category: Roth BL]]
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[[Category: Schapira, M]]
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[[Category: Schapira M]]
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[[Category: Schmidt, K]]
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[[Category: Schmidt K]]
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[[Category: Smil, D]]
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[[Category: Smil D]]
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[[Category: Szewczyk, M]]
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[[Category: Szewczyk M]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Vedadi, M]]
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[[Category: Vedadi M]]
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[[Category: Yang, X]]
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[[Category: Yang X]]
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[[Category: Yu, Z]]
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[[Category: Yu Z]]
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[[Category: Zang, I]]
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[[Category: Zang I]]
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[[Category: Zhao, K]]
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[[Category: Zhao K]]
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[[Category: Prmt3]]
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[[Category: Sgc707]]
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[[Category: Transferase]]
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Revision as of 10:34, 15 March 2023

Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea

PDB ID 4ryl

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OCA

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