4s12

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==1.55 Angstrom Crystal Structure of N-acetylmuramic acid 6-phosphate Etherase from Yersinia enterocolitica.==
==1.55 Angstrom Crystal Structure of N-acetylmuramic acid 6-phosphate Etherase from Yersinia enterocolitica.==
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<StructureSection load='4s12' size='340' side='right' caption='[[4s12]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='4s12' size='340' side='right'caption='[[4s12]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4s12]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Yere1 Yere1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S12 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4s12]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica_subsp._palearctica_Y11 Yersinia enterocolitica subsp. palearctica Y11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S12 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">murQ, Y11_42431 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=930944 YERE1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s12 OCA], [https://pdbe.org/4s12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s12 RCSB], [https://www.ebi.ac.uk/pdbsum/4s12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s12 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylmuramic_acid_6-phosphate_etherase N-acetylmuramic acid 6-phosphate etherase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.126 4.2.1.126] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s12 OCA], [http://pdbe.org/4s12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s12 RCSB], [http://www.ebi.ac.uk/pdbsum/4s12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s12 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/E7B2C4_YERE1 E7B2C4_YERE1]] Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.[HAMAP-Rule:MF_00068]
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[https://www.uniprot.org/uniprot/A0A0H2UKZ5_YERE1 A0A0H2UKZ5_YERE1] Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.[HAMAP-Rule:MF_00068]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: N-acetylmuramic acid 6-phosphate etherase]]
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[[Category: Large Structures]]
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[[Category: Yere1]]
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[[Category: Yersinia enterocolitica subsp. palearctica Y11]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Structural genomic]]
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[[Category: Dubrovska I]]
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[[Category: Dubrovska, I]]
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[[Category: Flores K]]
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[[Category: Flores, K]]
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[[Category: Grimshaw S]]
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[[Category: Grimshaw, S]]
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[[Category: Kwon K]]
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[[Category: Kwon, K]]
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[[Category: Minasov G]]
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[[Category: Minasov, G]]
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[[Category: Shuvalova L]]
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[[Category: Shuvalova, L]]
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[[Category: Csgid]]
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[[Category: Lyase]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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Revision as of 10:38, 15 March 2023

1.55 Angstrom Crystal Structure of N-acetylmuramic acid 6-phosphate Etherase from Yersinia enterocolitica.

PDB ID 4s12

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