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4s2t

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==Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: a cytosolic enzyme with a di-nuclear active site==
==Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: a cytosolic enzyme with a di-nuclear active site==
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<StructureSection load='4s2t' size='340' side='right' caption='[[4s2t]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='4s2t' size='340' side='right'caption='[[4s2t]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4s2t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S2T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4s2t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S2T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=01B:(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOIC+ACID'>01B</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=01B:(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOIC+ACID'>01B</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s2t OCA], [https://pdbe.org/4s2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s2t RCSB], [https://www.ebi.ac.uk/pdbsum/4s2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s2t ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s2r|4s2r]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">app-1, CELE_W03G9.4, W03G9.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s2t OCA], [http://pdbe.org/4s2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s2t RCSB], [http://www.ebi.ac.uk/pdbsum/4s2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s2t ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/XPP_CAEEL XPP_CAEEL] Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11606206, PubMed:25905034). Has activity towards the flp-9 neuropeptide KPSFVRF-amide (PubMed:11606206).<ref>PMID:11606206</ref> <ref>PMID:25905034</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4s2t" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4s2t" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caeel]]
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[[Category: Caenorhabditis elegans]]
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[[Category: Acharya, K R]]
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[[Category: Large Structures]]
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[[Category: Isaac, R E]]
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[[Category: Acharya KR]]
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[[Category: Iyer, S]]
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[[Category: Isaac RE]]
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[[Category: La-Borde, P]]
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[[Category: Iyer S]]
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[[Category: Parsons, M R]]
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[[Category: La-Borde P]]
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[[Category: Payne, K A.P]]
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[[Category: Parsons MR]]
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[[Category: Turner, A J]]
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[[Category: Payne KAP]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Turner AJ]]
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[[Category: Metalloprotease]]
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[[Category: Pitta-bread fold]]
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[[Category: Zinc binding]]
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Revision as of 10:41, 15 March 2023

Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: a cytosolic enzyme with a di-nuclear active site

PDB ID 4s2t

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