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4tmv
From Proteopedia
(Difference between revisions)
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<StructureSection load='4tmv' size='340' side='right'caption='[[4tmv]], [[Resolution|resolution]] 1.53Å' scene=''> | <StructureSection load='4tmv' size='340' side='right'caption='[[4tmv]], [[Resolution|resolution]] 1.53Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4tmv]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4tmv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TMV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmv OCA], [https://pdbe.org/4tmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tmv RCSB], [https://www.ebi.ac.uk/pdbsum/4tmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tmv ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IF2P_CHATD IF2P_CHATD] Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.<ref>PMID:24686316</ref> <ref>PMID:25225612</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Chaetomium thermophilum]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ficner | + | [[Category: Ficner R]] |
| - | [[Category: Kuhle | + | [[Category: Kuhle B]] |
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Revision as of 10:46, 15 March 2023
Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTPgammaS and Sodium
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