4tpp

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==2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors==
==2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors==
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<StructureSection load='4tpp' size='340' side='right' caption='[[4tpp]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='4tpp' size='340' side='right'caption='[[4tpp]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TPP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TPP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35D:1-[4-(3-{[1-(QUINOLIN-2-YL)AZETIDIN-3-YL]OXY}QUINOXALIN-2-YL)PIPERIDIN-1-YL]ETHANONE'>35D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=35D:1-[4-(3-{[1-(QUINOLIN-2-YL)AZETIDIN-3-YL]OXY}QUINOXALIN-2-YL)PIPERIDIN-1-YL]ETHANONE'>35D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpm|4tpm]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpp OCA], [https://pdbe.org/4tpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tpp RCSB], [https://www.ebi.ac.uk/pdbsum/4tpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpp ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpp OCA], [http://pdbe.org/4tpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tpp RCSB], [http://www.ebi.ac.uk/pdbsum/4tpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpp ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4tpp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4tpp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chmait, S]]
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[[Category: Large Structures]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Chmait S]]
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[[Category: Phosphodiesterase 10a]]
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[[Category: Quinoline]]
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Revision as of 10:48, 15 March 2023

2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors

PDB ID 4tpp

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