Glutamate receptor 3D structures
From Proteopedia
(Difference between revisions)
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**[[5ybg]], [[5ybf]] - hIGluR2 LBD + potentiator + Glu<br /> | **[[5ybg]], [[5ybf]] - hIGluR2 LBD + potentiator + Glu<br /> | ||
**[[4u1y]], [[4u2p]], [[5l1b]] - rIGluR2 <br /> | **[[4u1y]], [[4u2p]], [[5l1b]] - rIGluR2 <br /> | ||
| + | **[[[6dlz]], [7rz9]] – rGluR2 – Cryo EM <br /> | ||
**[[5vov]], [[5vou]], [[5vot]] - rIGluR2 + calcium channel γ-2 – Cryo EM<br /> | **[[5vov]], [[5vou]], [[5vot]] - rIGluR2 + calcium channel γ-2 – Cryo EM<br /> | ||
**[[3n6v]], [[3o2j]], [[5n6p]] - rIGluR2 ATD (mutant) – rat<br /> | **[[3n6v]], [[3o2j]], [[5n6p]] - rIGluR2 ATD (mutant) – rat<br /> | ||
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**[[3t93]], [[4u2r]] - rIGluR2 LBD (mutant)<br /> | **[[3t93]], [[4u2r]] - rIGluR2 LBD (mutant)<br /> | ||
**[[5fth]], [[5fti]], [[5ns9]] - rIGluR2 LBD (mutant) + Glu<br /> | **[[5fth]], [[5fti]], [[5ns9]] - rIGluR2 LBD (mutant) + Glu<br /> | ||
| + | **[[5kbs]], [[5kbt]], [[5kbu]] - rIGluR2 + antagonist – Cryo-EM<br /> | ||
**[[5kk2]], [[5vov]], [[5vou]], [[5vot]] - rIGluR2 + calcium channel γ2 subunit – Cryo-EM<br /> | **[[5kk2]], [[5vov]], [[5vou]], [[5vot]] - rIGluR2 + calcium channel γ2 subunit – Cryo-EM<br /> | ||
**[[6ucb]], [[6ud4]], [[6ud8]] - rIGluR2 + CNIH-3 + antagonist – Cryo-EM<br /> | **[[6ucb]], [[6ud4]], [[6ud8]] - rIGluR2 + CNIH-3 + antagonist – Cryo-EM<br /> | ||
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**[[3h03]], [[3h06]], [[3b7d]], [[1n0t]], [[1ftl]], [[3tza]], [[3ua8]], [[4isu]], [[5cbs]], [[5cbr]], [[4yma]], [[6xsr]], [[6yk2]], [[6yk3]], [[6yk4]], [[6yk5]], [[6yk6]] - rIGluR2 LBD + antagonist<br /> | **[[3h03]], [[3h06]], [[3b7d]], [[1n0t]], [[1ftl]], [[3tza]], [[3ua8]], [[4isu]], [[5cbs]], [[5cbr]], [[4yma]], [[6xsr]], [[6yk2]], [[6yk3]], [[6yk4]], [[6yk5]], [[6yk6]] - rIGluR2 LBD + antagonist<br /> | ||
**[[1lb9]], [[4l17]], [[4u21]], [[4u22]], [[4u23]], [[5kbv]] - rIGluR2 LBD (mutant) + antagonist<br /> | **[[1lb9]], [[4l17]], [[4u21]], [[4u22]], [[4u23]], [[5kbv]] - rIGluR2 LBD (mutant) + antagonist<br /> | ||
| + | **[[5wek]], [[7rz4]], [[7rz5]] – rGluR2 + antagonist – Cryo EM <br /> | ||
*''GluR2 agonist complex'' | *''GluR2 agonist complex'' | ||
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**[[1lbc]], [[5elv]] - rIGluR2 LBD (mutant) + agonist + Glu<br /> | **[[1lbc]], [[5elv]] - rIGluR2 LBD (mutant) + agonist + Glu<br /> | ||
**[[2p2a]], [[5buu]], [[6hch]], [[6hcc]], [[6hcb]] - rIGluR2 LBD + agonist + Glu<br /> | **[[2p2a]], [[5buu]], [[6hch]], [[6hcc]], [[6hcb]] - rIGluR2 LBD + agonist + Glu<br /> | ||
| + | **[[7ryy]], [[7ryz]], [[7rz7]], [[7rz8]], [[7rza]] – rGluR2 + agonist – Cryo EM <br /> | ||
*''GluR2 partial agonist complex'' | *''GluR2 partial agonist complex'' | ||
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**[[5l2e]] – rIGluRδ2 extracellular domain<br /> | **[[5l2e]] – rIGluRδ2 extracellular domain<br /> | ||
**[[6lu9]] – rIGluRδ2 extracellular domain – Cryo EM<br /> | **[[6lu9]] – rIGluRδ2 extracellular domain – Cryo EM<br /> | ||
| + | **[[7z2r]] – rIGluRd2 LBD <br /> | ||
**[[5cc2]] – rIGluRδ2 LBD + agonist<br /> | **[[5cc2]] – rIGluRδ2 LBD + agonist<br /> | ||
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**[[7occ]] – rIGluR1 + rGluR2 – Cryo EM <br /> | **[[7occ]] – rIGluR1 + rGluR2 – Cryo EM <br /> | ||
| - | **[[6qkz]], [[6qkc]], [[7ocd]] – rIGluR1 + rGluR2 + calcium channel γ-8 – Cryo EM <br /> | + | **[[6qkz]], [[6qkc]], [[7ocd]], [[7qhh]] – rIGluR1 + rGluR2 + calcium channel γ-8 – Cryo EM <br /> |
| - | **[[7oca]], [[7ocf]] – rIGluR1 + rGluR2 + calcium channel γ-8 + CNIH2 – Cryo EM <br /> | + | **[[7oca]], [[7oce]], [[7ocf]] – rIGluR1 + rGluR2 + calcium channel γ-8 + CNIH2 – Cryo EM <br /> |
| + | **[[5weo]], [[7tnk]], [[7tnl]], [[7tnm]], [[7tnn]], [[7tno]], [[7tnp]] – rIGluR1/calcium channel g-8 + drug – Cryo EM <br /> | ||
**[[6njl]] – rIGluR1 + rGluR2 + calcium channel γ-8 + SCFV + auxiliary protein + antibody – Cryo EM <br /> | **[[6njl]] – rIGluR1 + rGluR2 + calcium channel γ-8 + SCFV + auxiliary protein + antibody – Cryo EM <br /> | ||
| + | **[[7ryz]], [[7rz8]] – rGluR2 + agonist – Cryo EM <br /> | ||
| + | **[[7rz5]] – rGluR2 + antagonist – Cryo EM <br /> | ||
| + | **[[7qhb]], [[7rz6]] – rGluR2 + Glu – Cryo EM <br /> | ||
| + | **[[6dm1]], [[6o9g]] – rGluR2 + Glu + inhibitor – Cryo EM <br /> | ||
| + | **[[6dm0]] – rGluR2 + Glu + drug – Cryo EM <br /> | ||
| + | **[[7tnj]] – rGluR2 + drug – Cryo EM <br /> | ||
| + | **[[6zyu]] – rGluR2 LBD + Glu + inhibitor<br /> | ||
**[[6ovd]], [[6ove]] – rIGluR1 + rGluR2 residues 415-821 + antagonist<br /> | **[[6ovd]], [[6ove]] – rIGluR1 + rGluR2 residues 415-821 + antagonist<br /> | ||
**[[7ldd]], [[7lde]] – mIGluR1 + mGluR2 + calcium channel γ-8 + SCFV + antibody – Cryo EM <br /> | **[[7ldd]], [[7lde]] – mIGluR1 + mGluR2 + calcium channel γ-8 + SCFV + antibody – Cryo EM <br /> | ||
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*Ionotropic kainate receptor 1 | *Ionotropic kainate receptor 1 | ||
| + | **[[7lvt]] – rGluK1 + Glu – Cryo EM<br /> | ||
**[[1ycj]] – rGluK1 LBD + Glu<br /> | **[[1ycj]] – rGluK1 LBD + Glu<br /> | ||
**[[5nf5]], [[5neb]] – rGluK1 LBD + Glu analog<br /> | **[[5nf5]], [[5neb]] – rGluK1 LBD + Glu analog<br /> | ||
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*Ionotropic kainate receptor 2 | *Ionotropic kainate receptor 2 | ||
| + | **[[7f56]], [[7f57]], [[7f59]], [[7f5a]], [[7f5b]] - rGluK2 (mutant) + NETO2 – Cryo EM<br /> | ||
**[[3qxm]] - hGluK2 LBD + toxin<br /> | **[[3qxm]] - hGluK2 LBD + toxin<br /> | ||
**[[2xxr]] – rGluK2 LBD + Glu<br /> | **[[2xxr]] – rGluK2 LBD + Glu<br /> | ||
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*Ionotropic kainate receptor 3 | *Ionotropic kainate receptor 3 | ||
| - | **[[6jfy]], [[6jfz]], [[6kzm]], [[6l6f]] - rGluK3 (mutant) – Cryo EM<br /> | + | **[[6jfy]], [[6jfz]], [[6kzm]], [[6l6f]], [[7vm2]] - rGluK3 (mutant) – Cryo EM<br /> |
**[[3olz]] – rGluK3 ATD<br /> | **[[3olz]] – rGluK3 ATD<br /> | ||
**[[6fjz]], [[6fjy]] - rGluK3 extracellular domain (mutant)<br /> | **[[6fjz]], [[6fjy]] - rGluK3 extracellular domain (mutant)<br /> | ||
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**[[3qlu]] - rGluK5 + rGluK2 (mutant)<br /> | **[[3qlu]] - rGluK5 + rGluK2 (mutant)<br /> | ||
**[[3qlv]] - rGluK5 + rGluK2 | **[[3qlv]] - rGluK5 + rGluK2 | ||
| - | |||
| - | |||
*NMDA receptor (NMDAR) | *NMDA receptor (NMDAR) | ||
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**[[7ujt]], [[7kl1]] - hNMDAR 1289-1310 (mutant) + CAMK2A + ATP<br /> | **[[7ujt]], [[7kl1]] - hNMDAR 1289-1310 (mutant) + CAMK2A + ATP<br /> | ||
**[[3jpy]], [[3jpw]] - rNMDAR ATD (mutant)<br /> | **[[3jpy]], [[3jpw]] - rNMDAR ATD (mutant)<br /> | ||
| - | **[[5up2]], [[5uow]] - XlNMDAR + NR2A + Fab + | + | **[[7ujr]] - rNMDAR 1289-1310 + CAMK2A <br /> |
| - | **[[5un1]] - XlNMDAR + methyl-aspartate receptor + | + | **[[5up2]], [[5uow]] - XlNMDAR + NR2A + Fab + Glu – Cryo-EM<br /> |
| + | **[[5un1]] - XlNMDAR + methyl-aspartate receptor + Glu <br /> | ||
*''NMDAR subunit NR3A'' | *''NMDAR subunit NR3A'' | ||
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*''NMDAR subunit NR1+NR2A'' | *''NMDAR subunit NR1+NR2A'' | ||
| - | **[[7eos]] – hNMDAR (mutant) – Cryo EM<br /> | + | **[[7eos]], [[7eou]] – hNMDAR (mutant) – Cryo EM<br /> |
**[[5h8f]] – hNMDAR LBD <br /> | **[[5h8f]] – hNMDAR LBD <br /> | ||
**[[6mmx]], [[6mmw]], [[6mmv]], [[6mmu]], [[6mmt]], [[6mms]], [[6mmr]], [[6mmp]], [[6mmn]], [[6mmm]], [[6mml]], [[6mmk]], [[6mmj]], [[6mmi]], [[6mmh]], [[6mmg]], [[6mmb]], [[6mma]], [[6mm9]], [[6irh]], [[6irg]], [[6irf]], [[6ira]], [[6mm9]], [[6mma]], [[6mmb]], [[6mmg]], [[6mmh]], [[6mmi]], [[6mmj]], [[6mmk]], [[6mml]], [[6mmm]], [[6mmn]], [[6mmp]], [[6mmr]], [[6mms]], [[6mmt]], [[6mmu]], [[6mmv]], [[6mmw]], [[6mmx]] – rNMDAR – Cryo EM <br /> | **[[6mmx]], [[6mmw]], [[6mmv]], [[6mmu]], [[6mmt]], [[6mms]], [[6mmr]], [[6mmp]], [[6mmn]], [[6mmm]], [[6mml]], [[6mmk]], [[6mmj]], [[6mmi]], [[6mmh]], [[6mmg]], [[6mmb]], [[6mma]], [[6mm9]], [[6irh]], [[6irg]], [[6irf]], [[6ira]], [[6mm9]], [[6mma]], [[6mmb]], [[6mmg]], [[6mmh]], [[6mmi]], [[6mmj]], [[6mmk]], [[6mml]], [[6mmm]], [[6mmn]], [[6mmp]], [[6mmr]], [[6mms]], [[6mmt]], [[6mmu]], [[6mmv]], [[6mmw]], [[6mmx]] – rNMDAR – Cryo EM <br /> | ||
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**[[5tpa]], [[5tp9]] – hNMDAR LBD + antagonist<br /> | **[[5tpa]], [[5tp9]] – hNMDAR LBD + antagonist<br /> | ||
| - | **[[7eoq]], [[7eot]] – hNMDAR (mutant) + antagonist – Cryo EM<br /> | + | **[[7eoq]], [[7eor]], [[7eot]] – hNMDAR (mutant) + antagonist – Cryo EM<br /> |
**[[5kdt]], [[5kcj]] – hNMDAR LBD + modulator<br /> | **[[5kdt]], [[5kcj]] – hNMDAR LBD + modulator<br /> | ||
**[[5tpa]], [[5tp9]], [[5kdt]], [[5kcj]], [[5i2n]], [[5i2k]], [[5h8q]], [[5h8n]], [[5h8h]] – hNMDAR LBD + allosteric modulator<br /> | **[[5tpa]], [[5tp9]], [[5kdt]], [[5kcj]], [[5i2n]], [[5i2k]], [[5h8q]], [[5h8n]], [[5h8h]] – hNMDAR LBD + allosteric modulator<br /> | ||
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**[[5tpz]] – rNMDAR LBD <br /> | **[[5tpz]] – rNMDAR LBD <br /> | ||
**[[6wi0]] – rNMDAR + antagonist – Cryo EM <br /> | **[[6wi0]] – rNMDAR + antagonist – Cryo EM <br /> | ||
| + | **[[7te9]], [[7teb]], [[7tee]], [[7teq]], [[7tes]] – rNMDAR + antibody – Cryo EM <br /> | ||
| + | **[[7eu7]], [[7eu8]], [[7sac]] – rNMDAR + ketamine + Glu – Cryo EM <br /> | ||
| + | **[[7saa]] – rNMDAR + Glu – Cryo EM <br /> | ||
| + | **[[7sab]] – rNMDAR + PCP – Cryo EM <br /> | ||
| + | **[[7sad]] – rNMDAR + drug – Cryo EM <br /> | ||
**[[4pe5]], [[4tll]], [[4tlm]] – rNMDAR (mutants)<br /> | **[[4pe5]], [[4tll]], [[4tlm]] – rNMDAR (mutants)<br /> | ||
**[[5b3j]] – XlNMDAR1 ATD (mutant) + rNMDAR2B ATD (mutant) + antibody<br /> | **[[5b3j]] – XlNMDAR1 ATD (mutant) + rNMDAR2B ATD (mutant) + antibody<br /> | ||
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**[[5ipu]], [[6e7x]], [[6e7w]], [[6e7v]], [[6e7u]], [[6e7t]], [[6e7s]], [[6e7r]] – XlNMDAR2B (mutant) + NMDAR1 (mutant) + inhibitor<br /> | **[[5ipu]], [[6e7x]], [[6e7w]], [[6e7v]], [[6e7u]], [[6e7t]], [[6e7s]], [[6e7r]] – XlNMDAR2B (mutant) + NMDAR1 (mutant) + inhibitor<br /> | ||
**[[3qel]], [[3qem]], [[5ewj]] – XlNMDAR ATD (mutant) + ifenprodil<br /> | **[[3qel]], [[3qem]], [[5ewj]] – XlNMDAR ATD (mutant) + ifenprodil<br /> | ||
| + | |||
| + | *''NMDAR subunit NR1+NR2C'' | ||
| + | |||
| + | **[[8e94]], [[8e97]] – hNMDAR – Cryo EM <br /> | ||
| + | **[[8e92]], [[8e93]], [[8e96]], [[8e98]] – hNMDAR + Glu + cyclo-Ser – Cryo EM <br /> | ||
| + | |||
| + | *''NMDAR subunit NR1+NR2A+NR2C'' | ||
| + | |||
| + | **[[8e99]] – hNMDAR + nanobody – Cryo EM <br /> | ||
*''NMDAR subunit NR1B+NR2B'' | *''NMDAR subunit NR1B+NR2B'' | ||
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**[[6wi1]], [[6whr]], [[6whs]], [[6wht]], [[6whu]], [[6whv]] – rNMDAR – Cryo EM <br /> | **[[6wi1]], [[6whr]], [[6whs]], [[6wht]], [[6whu]], [[6whv]] – rNMDAR – Cryo EM <br /> | ||
**[[6whw]], [[6whx]], [[6why]] – rNMDAR + antagonist – Cryo EM <br /> | **[[6whw]], [[6whx]], [[6why]] – rNMDAR + antagonist – Cryo EM <br /> | ||
| + | **[[7ter]], [[7tet]] – rNMDAR + antibody – Cryo EM <br /> | ||
| + | **[[7te6]] – rNMDAR ATD + antibody <br /> | ||
| + | **[[8g18]] – rNMDAR ATD + inhibitor<br /> | ||
*NMDAR subunit NR1+NR2A+NR2B | *NMDAR subunit NR1+NR2A+NR2B | ||
Revision as of 08:50, 16 March 2023
3D structures of glutamate receptor
Updated on 16-March-2023
A topic page describing in detail the GluA2 structure described in 3kg2
