Glutaminyl cyclase

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Line 23: Line 23:
**[[2afm]], [[2afo]] – hQC – human <br />
**[[2afm]], [[2afo]] – hQC – human <br />
**[[2afs]], [[2zed]], [[2zee]], [[2zef]], [[2zeg]], [[2zeh]], [[2zel]], [[2zem]], [[2zen]], [[2zeo]], [[2zep]], [[3pbe]], [[4yu9]], [[7cp0]] – hQC (mutant) <br />
**[[2afs]], [[2zed]], [[2zee]], [[2zef]], [[2zeg]], [[2zeh]], [[2zel]], [[2zem]], [[2zen]], [[2zeo]], [[2zep]], [[3pbe]], [[4yu9]], [[7cp0]] – hQC (mutant) <br />
 +
**[[3pb4]], [[3pb6]] – hQC catalytic domain 28-382<br />
**[[3si1]] – mQC – mouse <br />
**[[3si1]] – mQC – mouse <br />
-
**[[4fwu]], [[4f9u]] – DmQC – ''Drosophila melanogaster'' <br />
+
**[[4fai]], [[4fwu]], [[4f9u]] – DmQC – ''Drosophila melanogaster'' <br />
-
**[[4f9v]] – DmQC (mutant) <br />
+
**[[4f9v]], [[4fbe]] – DmQC (mutant) <br />
 +
**[[2faw]] – QC – papaya<br />
**[[3mbr]] – QC – ''Xanthomonas campestris'' <br />
**[[3mbr]] – QC – ''Xanthomonas campestris'' <br />
-
**[[3nol]] – QC – ''Zymomonas mobilis'' <br />
+
**[[3nol]], [[3nom]] – QC – ''Zymomonas mobilis'' <br />
**[[3nok]] – QC – ''Myxococcus xanthus''<br />
**[[3nok]] – QC – ''Myxococcus xanthus''<br />
-
**[[7d1n]], [[7d1p]], [[7d1y]], [[7d21]], [[7d23]], [[7d2b]], [[7d2d]], [[7d2i]], [[7d2j]] – IsQC – ''Ixodes scapularis''<br />
+
**[[4mhn]], [[4mhp]], [[7d1n]], [[7d1p]], [[7d1y]], [[7d21]], [[7d23]], [[7d2b]], [[7d2d]], [[7d2i]], [[7d2j]] – IsQC catalytic domain – ''Ixodes scapularis''<br />
-
**[[7d1h]] – IsQC (mutant) <br />
+
**[[7d1h]] – IsQC catalytic domain (mutant) <br />
**[[7d17]] – QC – ''Macrostormum lignano''<br />
**[[7d17]] – QC – ''Macrostormum lignano''<br />
**[[6qql]], [[7cje]], [[7cjg]] – QC – ''Porphyromonas gingivalis''<br />
**[[6qql]], [[7cje]], [[7cjg]] – QC – ''Porphyromonas gingivalis''<br />
Line 41: Line 43:
**[[2afu]] – hQC + glutamine t-butyl ester <br />
**[[2afu]] – hQC + glutamine t-butyl ester <br />
**[[2afw]] – hQC + N-acetylhistamine <br />
**[[2afw]] – hQC + N-acetylhistamine <br />
-
**[[2afx]], [[3si0]], [[2afz]] – hQC + imidazole derivative<br />
+
**[[2afx]], [[3si0]], [[2afz]], [[3pb9]], [[7cm0]], [[7d8e]] – hQC catalytic domain + imidazole derivative<br />
-
**[[3pbb]] – hQC + inhibitor <br />
+
**[[3pb7]], [[3pb8]], [[3pbb]] – hQC catalytic domain + inhibitor <br />
**[[4ywy]], [[6gbx]], [[7coz]] – hQC (mutant) + inhibitor <br />
**[[4ywy]], [[6gbx]], [[7coz]] – hQC (mutant) + inhibitor <br />
**[[6yi1]] – hQC + Glu-(γ-hydrazide)-Phe-Ala<br />
**[[6yi1]] – hQC + Glu-(γ-hydrazide)-Phe-Ala<br />
**[[6yjy]] – hQC + neurotensin<br />
**[[6yjy]] – hQC + neurotensin<br />
**[[3si2]] – mQC + inhibitor <br />
**[[3si2]] – mQC + inhibitor <br />
-
**[[7d1d]] – QC + imidazole derivative – ''Bacterioides thetaiotaomicron''<br />
+
**[[7d1d]] – BtQC + imidazole derivative – ''Bacterioides thetaiotaomicron''<br />
 +
**[[7d1e]] – BtQC + N-acetylhistamine <br />
 +
**[[4mhz]] – IsQC catalytic domain (mutant) + inhibitor <br />
 +
**[[4mhy]] – IsQC catalytic domain + imidazole derivative<br />
}}
}}

Revision as of 10:45, 16 March 2023

Structure of human glutaminyl cyclase complex with benzyimidazole and Zn+2 ion (PDB code 2afx).

Drag the structure with the mouse to rotate

3D Structures of glutaminyl cyclase

Updated on 16-March-2023

References

  1. ↑ Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS. An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes. J Biol Chem. 1987 Jun 25;262(18):8532-6. PMID:3597387
  2. ↑ Valenti MT, Bolognin S, Zanatta C, Donatelli L, Innamorati G, Pampanin M, Zanusso G, Zatta P, Dalle Carbonare L. Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. J Alzheimers Dis. 2013;34(1):263-71. doi: 10.3233/JAD-120517. PMID:23207485 doi:http://dx.doi.org/10.3233/JAD-120517
  3. ↑ Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13117-22. Epub 2005 Aug 31. PMID:16135565

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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