1k8i

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[[Image:1k8i.jpg|left|200px]]
[[Image:1k8i.jpg|left|200px]]
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{{Structure
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|PDB= 1k8i |SIZE=350|CAPTION= <scene name='initialview01'>1k8i</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1k8i", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= H2-DM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1k8i| PDB=1k8i | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8i OCA], [http://www.ebi.ac.uk/pdbsum/1k8i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k8i RCSB]</span>
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'''CRYSTAL STRUCTURE OF MOUSE H2-DM'''
'''CRYSTAL STRUCTURE OF MOUSE H2-DM'''
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[[Category: Kappler, J.]]
[[Category: Kappler, J.]]
[[Category: Marrack, P.]]
[[Category: Marrack, P.]]
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[[Category: mhc]]
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[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:54 2008''
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Revision as of 19:26, 2 May 2008

Image:1k8i.jpg

Template:STRUCTURE 1k8i

CRYSTAL STRUCTURE OF MOUSE H2-DM


Overview

H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where it facilitates the loading of antigenic peptides into the peptide-binding groove of class II MHC. The crystal structure of a soluble form of H2-M has been solved to 3.1 A resolution, revealing a heterodimer with structural similarities to the MHC family of proteins. In contrast to its antigen-presenting cousins, the membrane distal alpha helices of H2-M pack closely together, occluding most of the binding groove except for a single large pocket near the center. The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor.

About this Structure

1K8I is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:9768758 Page seeded by OCA on Fri May 2 22:26:01 2008

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