1k8k

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[[Image:1k8k.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8k OCA], [http://www.ebi.ac.uk/pdbsum/1k8k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k8k RCSB]</span>
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'''Crystal Structure of Arp2/3 Complex'''
'''Crystal Structure of Arp2/3 Complex'''
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[[Category: Robinson, R C.]]
[[Category: Robinson, R C.]]
[[Category: Turbedsky, K.]]
[[Category: Turbedsky, K.]]
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[[Category: beta-propeller]]
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[[Category: Beta-propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:53 2008''
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Revision as of 19:26, 2 May 2008

Image:1k8k.gif

Template:STRUCTURE 1k8k

Crystal Structure of Arp2/3 Complex


Overview

We determined a crystal structure of bovine Arp2/3 complex, an assembly of seven proteins that initiates actin polymerization in eukaryotic cells, at 2.0 angstrom resolution. Actin-related protein 2 (Arp2) and Arp3 are folded like actin, with distinctive surface features. Subunits ARPC2 p34 and ARPC4 p20 in the core of the complex associate through long carboxyl-terminal alpha helices and have similarly folded amino-terminal alpha/beta domains. ARPC1 p40 is a seven-blade beta propeller with an insertion that may associate with the side of an actin filament. ARPC3 p21 and ARPC5 p16 are globular alpha-helical subunits. We predict that WASp/Scar proteins activate Arp2/3 complex by bringing Arp2 into proximity with Arp3 for nucleation of a branch on the side of a preexisting actin filament.

About this Structure

1K8K is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Arp2/3 complex., Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD, Science. 2001 Nov 23;294(5547):1679-84. PMID:11721045 Page seeded by OCA on Fri May 2 22:26:13 2008

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