1k8w

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[[Image:1k8w.gif|left|200px]]
[[Image:1k8w.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1k8w |SIZE=350|CAPTION= <scene name='initialview01'>1k8w</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1k8w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=FHU:(5S,6R)-5-FLUORO-6-HYDROXY-PSEUDOURIDINE-5&#39;-MONOPHOSPHATE'>FHU</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1k8w| PDB=1k8w | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8w OCA], [http://www.ebi.ac.uk/pdbsum/1k8w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k8w RCSB]</span>
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}}
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'''Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA'''
'''Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA'''
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[[Category: Amare, A R.Ferre-D.]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Hoang, C.]]
[[Category: Hoang, C.]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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[[Category: t stem-loop]]
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[[Category: T stem-loop]]
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[[Category: trna]]
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[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:45:00 2008''
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Revision as of 19:27, 2 May 2008

Image:1k8w.gif

Template:STRUCTURE 1k8w

Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA


Overview

Pseudouridine (Psi) synthases catalyze the isomerization of specific uridines in cellular RNAs to pseudouridines and may function as RNA chaperones. TruB is responsible for the Psi residue present in the T loops of virtually all tRNAs. The close homolog Cbf5/dyskerin is the catalytic subunit of box H/ACA snoRNPs. These carry out the pseudouridylation of eukaryotic rRNA and snRNAs. The 1.85 A resolution structure of TruB bound to RNA reveals that this enzyme recognizes the preformed three-dimensional structure of the T loop, primarily through shape complementarity. It accesses its substrate uridyl residue by flipping out the nucleotide and disrupts the tertiary structure of tRNA. Structural comparisons with TruB demonstrate that all Psi synthases are descended from a common molecular ancestor.

About this Structure

1K8W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme., Hoang C, Ferre-D'Amare AR, Cell. 2001 Dec 28;107(7):929-39. PMID:11779468 Page seeded by OCA on Fri May 2 22:26:59 2008

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