8c03

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'''Unreleased structure'''
 
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The entry 8c03 is ON HOLD until Paper Publication
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==Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy12 in outward-facing conformation==
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<StructureSection load='8c03' size='340' side='right'caption='[[8c03]], [[Resolution|resolution]] 3.89&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C03 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SZU:2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide'>SZU</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c03 OCA], [https://pdbe.org/8c03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c03 RCSB], [https://www.ebi.ac.uk/pdbsum/8c03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c03 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Hemochromatosis type 4. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071). Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).[UniProtKB:Q9JHI9]<ref>PMID:15692071</ref> <ref>PMID:22682227</ref> <ref>PMID:29237594</ref> <ref>PMID:32814342</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Drozdzyk K]]
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[[Category: Dutzler R]]
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[[Category: Lehmann EF]]
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[[Category: Liziczai M]]
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[[Category: Manatschal C]]

Revision as of 07:22, 22 March 2023

Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy12 in outward-facing conformation

PDB ID 8c03

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OCA

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