8ce6
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Cd11b I domain in C121 space group== | |
| - | + | <StructureSection load='8ce6' size='340' side='right'caption='[[8ce6]], [[Resolution|resolution]] 1.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ce6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CE6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ce6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ce6 OCA], [https://pdbe.org/8ce6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ce6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ce6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ce6 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Ni | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Coker J]] |
| - | [[Category: | + | [[Category: Gao Q]] |
| + | [[Category: Koekemoer L]] | ||
| + | [[Category: MacLean EM]] | ||
| + | [[Category: Marsden B]] | ||
| + | [[Category: Midwood K]] | ||
| + | [[Category: Ni X]] | ||
| + | [[Category: Schwenzer A]] | ||
| + | [[Category: Von Delft F]] | ||
| + | [[Category: Williams E]] | ||
| + | [[Category: Wright ND]] | ||
Revision as of 07:22, 22 March 2023
Crystal structure of human Cd11b I domain in C121 space group
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Categories: Homo sapiens | Large Structures | Coker J | Gao Q | Koekemoer L | MacLean EM | Marsden B | Midwood K | Ni X | Schwenzer A | Von Delft F | Williams E | Wright ND
