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4tyl

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<StructureSection load='4tyl' size='340' side='right'caption='[[4tyl]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4tyl' size='340' side='right'caption='[[4tyl]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tyl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TYL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TYL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39O:5-AMINO-1,3,6-TRIMETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE'>39O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=39O:5-AMINO-1,3,6-TRIMETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE'>39O</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tz2|4tz2]], [[4tz8|4tz8]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyl OCA], [https://pdbe.org/4tyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tyl RCSB], [https://www.ebi.ac.uk/pdbsum/4tyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyl ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tyl OCA], [http://pdbe.org/4tyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tyl RCSB], [http://www.ebi.ac.uk/pdbsum/4tyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tyl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
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[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenosinetriphosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chauder, B A]]
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[[Category: Chauder BA]]
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[[Category: Fesik, S W]]
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[[Category: Fesik SW]]
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[[Category: Harner, M J]]
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[[Category: Harner MJ]]
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[[Category: Phan, J]]
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[[Category: Phan J]]
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[[Category: Bromodomain]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Revision as of 07:52, 22 March 2023

Fragment-Based Screening of the Bromodomain of ATAD2

PDB ID 4tyl

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