4u42

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<StructureSection load='4u42' size='340' side='right'caption='[[4u42]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4u42' size='340' side='right'caption='[[4u42]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u42]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U42 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u42]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U42 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3C8:6-[(3S)-3-(4-METHYL-1H-PYRAZOL-3-YL)PIPERIDIN-1-YL]PYRIDO[3,2-D]PYRIMIDIN-4-AMINE'>3C8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3C8:6-[(3S)-3-(4-METHYL-1H-PYRAZOL-3-YL)PIPERIDIN-1-YL]PYRIDO[3,2-D]PYRIMIDIN-4-AMINE'>3C8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u3y|4u3y]], [[4u3z|4u3z]], [[4u40|4u40]], [[4u41|4u41]], [[4u43|4u43]], [[4u44|4u44]], [[4u45|4u45]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u42 OCA], [https://pdbe.org/4u42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u42 RCSB], [https://www.ebi.ac.uk/pdbsum/4u42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u42 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP4K4, HGK, KIAA0687, NIK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u42 OCA], [http://pdbe.org/4u42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u42 RCSB], [http://www.ebi.ac.uk/pdbsum/4u42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u42 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN]] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref>
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[https://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Coons M]]
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[[Category: Coons, M]]
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[[Category: Harris SF]]
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[[Category: Harris, S F]]
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[[Category: Wu P]]
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[[Category: Wu, P]]
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[[Category: Kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 08:00, 22 March 2023

MAP4K4 T181E Mutant Bound to inhibitor compound 1

PDB ID 4u42

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