4u5s
From Proteopedia
(Difference between revisions)
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<StructureSection load='4u5s' size='340' side='right'caption='[[4u5s]], [[Resolution|resolution]] 2.12Å' scene=''> | <StructureSection load='4u5s' size='340' side='right'caption='[[4u5s]], [[Resolution|resolution]] 2.12Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4u5s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5S OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4u5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U5S FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3D0:N-[(2S)-2-[(N~2~-ACETYL-D-LYSYL)AMINO]-3-(PYRIDIN-3-YLMETHOXY)PROPYL]-L-ALLOTHREONYL-D-PHENYLALANINAMIDE'>3D0</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D0:N-[(2S)-2-[(N~2~-ACETYL-D-LYSYL)AMINO]-3-(PYRIDIN-3-YLMETHOXY)PROPYL]-L-ALLOTHREONYL-D-PHENYLALANINAMIDE'>3D0</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5s OCA], [https://pdbe.org/4u5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u5s RCSB], [https://www.ebi.ac.uk/pdbsum/4u5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5s ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4u5s" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4u5s" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Importin 3D structures|Importin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Holvey RS]] |
| - | [[Category: | + | [[Category: Stewart M]] |
| - | [[Category: | + | [[Category: Valkov E]] |
| - | + | ||
| - | + | ||
Revision as of 08:03, 22 March 2023
IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
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