4u5y

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<StructureSection load='4u5y' size='340' side='right'caption='[[4u5y]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='4u5y' size='340' side='right'caption='[[4u5y]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u5y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_paratyphi_b_str._atcc_10719 Salmonella enterica subsp. enterica serovar paratyphi b str. atcc 10719] and [http://en.wikipedia.org/wiki/Streptomyces_lividans_tk24 Streptomyces lividans tk24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U5Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Paratyphi_B_str._ATCC_10719 Salmonella enterica subsp. enterica serovar Paratyphi B str. ATCC 10719] and [https://en.wikipedia.org/wiki/Streptomyces_lividans_TK24 Streptomyces lividans TK24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U5Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nxy|4nxy]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5y OCA], [https://pdbe.org/4u5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u5y RCSB], [https://www.ebi.ac.uk/pdbsum/4u5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5y ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SSPG_01886 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=457428 Streptomyces lividans TK24]), acs, SEEPB719_19728 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=930774 Salmonella enterica subsp. enterica serovar Paratyphi B str. ATCC 10719])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate--CoA_ligase Acetate--CoA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.1 6.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5y OCA], [http://pdbe.org/4u5y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u5y RCSB], [http://www.ebi.ac.uk/pdbsum/4u5y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5y ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/V1Q8H8_SALET V1Q8H8_SALET]] Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.[HAMAP-Rule:MF_01123] Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.[HAMAP-Rule:MF_01123]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetate--CoA ligase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar paratyphi b str. atcc 10719]]
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[[Category: Salmonella enterica subsp. enterica serovar Paratyphi B str. ATCC 10719]]
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[[Category: Streptomyces lividans tk24]]
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[[Category: Streptomyces lividans TK24]]
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[[Category: Escalante-Semerena, J C]]
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[[Category: Escalante-Semerena JC]]
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[[Category: Rank, K C]]
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[[Category: Rank KC]]
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[[Category: Rayment, I]]
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[[Category: Rayment I]]
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[[Category: Taylor, K C]]
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[[Category: Taylor KC]]
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[[Category: Tucker, A C]]
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[[Category: Tucker AC]]
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[[Category: Acetylation]]
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[[Category: Complex]]
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[[Category: Gnat]]
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[[Category: Ligase]]
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[[Category: Pat]]
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Revision as of 08:04, 22 March 2023

Crystal Structure of the complex between the GNAT domain of S. lividans PAT and the acetyl-CoA synthetase C-terminal domain of S. enterica

PDB ID 4u5y

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