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4uft

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<SX load='4uft' size='340' side='right' viewer='molstar' caption='[[4uft]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
<SX load='4uft' size='340' side='right' viewer='molstar' caption='[[4uft]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meash Meash] and [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UFT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4UFT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_virus_strain_Halle Measles virus strain Halle] and [https://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UFT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4uft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uft OCA], [http://pdbe.org/4uft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uft RCSB], [http://www.ebi.ac.uk/pdbsum/4uft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uft ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uft OCA], [https://pdbe.org/4uft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uft RCSB], [https://www.ebi.ac.uk/pdbsum/4uft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uft ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCAP_MEASH NCAP_MEASH]] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.
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[https://www.uniprot.org/uniprot/NCAP_MEASH NCAP_MEASH] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Meash]]
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[[Category: Measles virus strain Halle]]
[[Category: Spodoptera frugiperda]]
[[Category: Spodoptera frugiperda]]
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[[Category: Desfosses, A]]
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[[Category: Desfosses A]]
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[[Category: Effantin, G]]
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[[Category: Effantin G]]
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[[Category: Gutsche, I]]
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[[Category: Gutsche I]]
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[[Category: Haupt, M]]
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[[Category: Haupt M]]
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[[Category: Ling, W L]]
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[[Category: Ling WL]]
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[[Category: Ruigrok, R W.H]]
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[[Category: Ruigrok RWH]]
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[[Category: Sachse, C]]
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[[Category: Sachse C]]
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[[Category: Schoehn, G]]
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[[Category: Schoehn G]]
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[[Category: Measles virus nucleocapsid]]
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[[Category: Rna binding protein]]
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[[Category: Transcription and replication template]]
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Revision as of 08:22, 22 March 2023

Structure of the helical Measles virus nucleocapsid

4uft, resolution 4.30Å

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