Sandbox Reserved 1794
From Proteopedia
(Difference between revisions)
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== Introduction == | == Introduction == | ||
| - | + | Sodium Taurocholate Co-Transporting Polypeptide, or NTCP, is a transporter protein that is found in | |
== Structure == | == Structure == | ||
[[Image:NTCP topography.jpeg|300px|left|thumb|cartoon depiction of NTCP topology]] | [[Image:NTCP topography.jpeg|300px|left|thumb|cartoon depiction of NTCP topology]] | ||
| - | Sodium Taurocholate Co-Transporting Polypeptide, or NTCP, is one continuous polypeptide chain consisting of a total of 9 transmembrane α helices (TM1-9). There are two distinct domains within the quaternary structure of NTCP: a <scene name='95/952722/Ntcp_core_domain-_blue/3'>core domain</scene> (blue) and a <scene name='95/952722/Ntcp_panel_domain-_red/2'>panel domain</scene> (red), both being a part of the same polypeptide chain. The core domain includes 6 transmembrane α helices (TM2-4 and TM7-9) while the panel domain consists of 3 transmembrane α helices (TM1 and TM5-6). Within the core domain, there is a unique crossover between TM-3 and TM-8 that is known as the <scene name='95/952722/Ntcp_x_motif/2'>X motif</scene>. | + | Sodium Taurocholate Co-Transporting Polypeptide, or NTCP, is one continuous polypeptide chain consisting of a total of 9 transmembrane α helices (TM1-9). There are two distinct domains within the quaternary structure of NTCP: a <scene name='95/952722/Ntcp_core_domain-_blue/3'>core domain</scene> (blue) and a <scene name='95/952722/Ntcp_panel_domain-_red/2'>panel domain</scene> (red), both being a part of the same polypeptide chain. The core domain includes 6 transmembrane α helices (TM2-4 and TM7-9) and demonstrates two-fold pseudosymmetry while the panel domain consists of 3 transmembrane α helices (TM1 and TM5-6) and does not display symmetry. Within the core domain, there is a unique crossover between TM-3 and TM-8 that is known as the <scene name='95/952722/Ntcp_x_motif/2'>X motif</scene>. This motif is important because this is where the transporter's substrate binding site is located. |
=== Conformational Change === | === Conformational Change === | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | <ref name="Stieger">PMID:21103971</ref>. | ||
Revision as of 17:12, 24 March 2023
| This Sandbox is Reserved from February 27 through August 31, 2023 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1765 through Sandbox Reserved 1795. |
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Sodium Taurocholate Co-Transporting Polypeptide
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References
[1].
