1kbg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1kbg.jpg|left|200px]]
[[Image:1kbg.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1kbg |SIZE=350|CAPTION= <scene name='initialview01'>1kbg</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_1kbg", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ESC:2-AMINO-4-ETHYL+SULFANYL+BUTYRIC+ACID'>ESC</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1kbg| PDB=1kbg | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kbg OCA], [http://www.ebi.ac.uk/pdbsum/1kbg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kbg RCSB]</span>
+
-
}}
+
'''MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2'''
'''MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2'''
Line 29: Line 26:
[[Category: Speir, J A.]]
[[Category: Speir, J A.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
-
[[Category: antigen presentation]]
+
[[Category: Antigen presentation]]
-
[[Category: cell surface receptor]]
+
[[Category: Cell surface receptor]]
-
[[Category: cellular immunity]]
+
[[Category: Cellular immunity]]
-
[[Category: glycopeptide]]
+
[[Category: Glycopeptide]]
-
[[Category: immunology]]
+
[[Category: Immunology]]
-
[[Category: major histocompatibility complex]]
+
[[Category: Major histocompatibility complex]]
-
[[Category: mhc]]
+
[[Category: Mhc]]
-
[[Category: synthetic peptide]]
+
[[Category: Synthetic peptide]]
-
[[Category: vaccine]]
+
[[Category: Vaccine]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:32:20 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:46:07 2008''
+

Revision as of 19:32, 2 May 2008

Image:1kbg.jpg

Template:STRUCTURE 1kbg

MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2


Overview

T cell receptor (TCR) recognition of nonpeptidic and modified peptide antigens has been recently uncovered but is still poorly understood. Immunization with an H-2Kb-restricted glycopeptide RGY8-6H-Gal2 generates a population of cytotoxic T cells that express both alpha/beta TCR, specific for glycopeptide, and gamma/delta TCR, specific for the disaccharide, even on glycolipids. The crystal structure of Kb/RGY8-6H-Gal2 now demonstrates that the peptide and H-2Kb structures are unaffected by the peptide glycosylation, but the central region of the putative TCR binding site is dominated by the extensive exposure of the tethered carbohydrate. These features of the Kb/RGY8-6H-Gal2 structure are consistent with the individual ligand binding preferences identified for the alpha/beta and gamma/delta TCRs and thus explain the generation of a carbohydrate-specific T cell response.

About this Structure

1KBG is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL., Speir JA, Abdel-Motal UM, Jondal M, Wilson IA, Immunity. 1999 Jan;10(1):51-61. PMID:10023770 Page seeded by OCA on Fri May 2 22:32:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kbg"
Personal tools