From Proteopedia
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| - | ==Herpes simplex virus 1 polymerase holoenzyme bound to DNA in both open/closed conformations==
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| - | <StructureSection load='7m5p' size='340' side='right'caption='[[7m5p]], [[Resolution|resolution]] 2.69Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[7m5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_KOS Human alphaherpesvirus 1 strain KOS] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M5P FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m5p OCA], [https://pdbe.org/7m5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m5p RCSB], [https://www.ebi.ac.uk/pdbsum/7m5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m5p ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [https://www.uniprot.org/uniprot/H9E937_HHV1 H9E937_HHV1] Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.[ARBA:ARBA00025601]
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Human alphaherpesvirus 1 strain KOS]]
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| - | [[Category: Large Structures]]
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| - | [[Category: Synthetic construct]]
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| - | [[Category: Abraham J]]
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| - | [[Category: Coen DM]]
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| - | [[Category: Hogle J]]
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| - | [[Category: Pan J]]
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| - | [[Category: Shankar S]]
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| - | [[Category: Yang P]]
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Current revision
REMOVED: The PDB entry 7m5p was removed.
