|
|
| Line 3: |
Line 3: |
| | <StructureSection load='4uto' size='340' side='right'caption='[[4uto]], [[Resolution|resolution]] 1.55Å' scene=''> | | <StructureSection load='4uto' size='340' side='right'caption='[[4uto]], [[Resolution|resolution]] 1.55Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4uto]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UTO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4uto]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UTO FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4utp|4utp]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uto OCA], [https://pdbe.org/4uto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uto RCSB], [https://www.ebi.ac.uk/pdbsum/4uto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uto ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uto OCA], [http://pdbe.org/4uto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uto RCSB], [http://www.ebi.ac.uk/pdbsum/4uto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uto ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/MTSA_STRPN MTSA_STRPN]] Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection. | + | [https://www.uniprot.org/uniprot/MTSA_STRPN MTSA_STRPN] Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 27: |
Line 26: |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Counago, R M]] | + | [[Category: Streptococcus pneumoniae]] |
| - | [[Category: Kobe, B]] | + | [[Category: Counago RM]] |
| - | [[Category: Luo, Z]] | + | [[Category: Kobe B]] |
| - | [[Category: Maher, M]] | + | [[Category: Luo Z]] |
| - | [[Category: Atp binding]]
| + | [[Category: Maher M]] |
| - | [[Category: Cassette transporter]]
| + | |
| - | [[Category: Metal binding protein]]
| + | |
| Structural highlights
Function
MTSA_STRPN Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection.
Publication Abstract from PubMed
Cadmium is a transition metal ion that is highly toxic in biological systems. Although relatively rare in the Earth's crust, anthropogenic release of cadmium since industrialization has increased biogeochemical cycling and the abundance of the ion in the biosphere. Despite this, the molecular basis of its toxicity remains unclear. Here we combine metal-accumulation assays, high-resolution structural data and biochemical analyses to show that cadmium toxicity, in Streptococcus pneumoniae, occurs via perturbation of first row transition metal ion homeostasis. We show that cadmium uptake reduces the millimolar cellular accumulation of manganese and zinc, and thereby increases sensitivity to oxidative stress. Despite this, high cellular concentrations of cadmium (~17 mM) are tolerated, with negligible impact on growth or sensitivity to oxidative stress, when manganese and glutathione are abundant. Collectively, this work provides insight into the molecular basis of cadmium toxicity in prokaryotes, and the connection between cadmium accumulation and oxidative stress.
Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.,Begg SL, Eijkelkamp BA, Luo Z, Counago RM, Morey JR, Maher MJ, Ong CL, McEwan AG, Kobe B, O'Mara ML, Paton JC, McDevitt CA Nat Commun. 2015 Mar 3;6:6418. doi: 10.1038/ncomms7418. PMID:25731976[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Begg SL, Eijkelkamp BA, Luo Z, Counago RM, Morey JR, Maher MJ, Ong CL, McEwan AG, Kobe B, O'Mara ML, Paton JC, McDevitt CA. Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nat Commun. 2015 Mar 3;6:6418. doi: 10.1038/ncomms7418. PMID:25731976 doi:http://dx.doi.org/10.1038/ncomms7418
|
