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4uye

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<StructureSection load='4uye' size='340' side='right'caption='[[4uye]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='4uye' size='340' side='right'caption='[[4uye]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UYE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9F9:N-[1,3-DIMETHYL-2-OXO-6-(PIPERIDIN-1-YL)-2,3-DIHYDRO-1H-BENZIMIDAZOL-5-YL]-2-METHOXYBENZAMIDE'>9F9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9F9:N-[1,3-DIMETHYL-2-OXO-6-(PIPERIDIN-1-YL)-2,3-DIHYDRO-1H-BENZIMIDAZOL-5-YL]-2-METHOXYBENZAMIDE'>9F9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uyd|4uyd]], [[4uyf|4uyf]], [[4uyg|4uyg]], [[4uyh|4uyh]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uye OCA], [https://pdbe.org/4uye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uye RCSB], [https://www.ebi.ac.uk/pdbsum/4uye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uye ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uye OCA], [http://pdbe.org/4uye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uye RCSB], [http://www.ebi.ac.uk/pdbsum/4uye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uye ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4uye" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4uye" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[Peregrin|Peregrin]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bamborough, P]]
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[[Category: Bamborough P]]
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[[Category: Chung, C]]
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[[Category: Chung C]]
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[[Category: Demont, E]]
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[[Category: Demont E]]
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[[Category: Antagonist]]
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[[Category: Epigenetic reader]]
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[[Category: Histone]]
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[[Category: Inhibitor]]
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[[Category: Transcription]]
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Revision as of 07:51, 29 March 2023

BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-dimethyl-2-oxo-6-(piperidin-1- yl)-2,3-dihydro-1H-1,3-benzodiazol-5-yl-2-methoxybenzamide

PDB ID 4uye

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