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| | <StructureSection load='4v1f' size='340' side='right'caption='[[4v1f]], [[Resolution|resolution]] 1.70Å' scene=''> | | <StructureSection load='4v1f' size='340' side='right'caption='[[4v1f]], [[Resolution|resolution]] 1.70Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4v1f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_phlei Mycobacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4V1F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4v1f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_phlei Mycolicibacterium phlei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V1F FirstGlance]. <br> |
| | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=BQ1:BEDAQUILINE'>BQ1</scene></td></tr> | | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=BQ1:BEDAQUILINE'>BQ1</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v1g|4v1g]], [[4v1h|4v1h]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1f OCA], [https://pdbe.org/4v1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v1f RCSB], [https://www.ebi.ac.uk/pdbsum/4v1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v1f ProSAT]</span></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4v1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v1f OCA], [http://pdbe.org/4v1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v1f RCSB], [http://www.ebi.ac.uk/pdbsum/4v1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v1f ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | </div> | | </div> |
| | <div class="pdbe-citations 4v1f" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 4v1f" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[ATPase 3D structures|ATPase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Mycobacterium phlei]] | + | [[Category: Mycolicibacterium phlei]] |
| - | [[Category: Meier, T]] | + | [[Category: Meier T]] |
| - | [[Category: Preiss, L]] | + | [[Category: Preiss L]] |
| - | [[Category: Yildiz, O]] | + | [[Category: Yildiz O]] |
| - | [[Category: Drug binding and inhibition]]
| + | |
| - | [[Category: F1fo-atp synthase rotor membrane protein structure]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| Structural highlights
Publication Abstract from PubMed
Multidrug-resistant tuberculosis (MDR-TB) is more prevalent today than at any other time in human history. Bedaquiline (BDQ), a novel Mycobacterium-specific adenosine triphosphate (ATP) synthase inhibitor, is the first drug in the last 40 years to be approved for the treatment of MDR-TB. This bactericidal compound targets the membrane-embedded rotor (c-ring) of the mycobacterial ATP synthase, a key metabolic enzyme required for ATP generation. We report the x-ray crystal structures of a mycobacterial c9 ring without and with BDQ bound at 1.55- and 1.7-A resolution, respectively. The structures and supporting functional assays reveal how BDQ specifically interacts with the rotor ring via numerous interactions and thereby completely covers the c-ring's ion-binding sites. This prevents the rotor ring from acting as an ion shuttle and stalls ATP synthase operation. The structures explain how diarylquinoline chemicals specifically inhibit the mycobacterial ATP synthase and thus enable structure-based drug design of next-generation ATP synthase inhibitors against Mycobacterium tuberculosis and other bacterial pathogens.
Structure of the mycobacterial ATP synthase F rotor ring in complex with the anti-TB drug bedaquiline.,Preiss L, Langer JD, Yildiz O, Eckhardt-Strelau L, Guillemont JE, Koul A, Meier T Sci Adv. 2015 May 8;1(4):e1500106. eCollection 2015 May. PMID:26601184[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Preiss L, Langer JD, Yildiz O, Eckhardt-Strelau L, Guillemont JE, Koul A, Meier T. Structure of the mycobacterial ATP synthase F rotor ring in complex with the anti-TB drug bedaquiline. Sci Adv. 2015 May 8;1(4):e1500106. eCollection 2015 May. PMID:26601184 doi:http://dx.doi.org/10.1126/sciadv.1500106
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